Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug

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dc.contributor.authorH Y Park-
dc.contributor.authorK S Oh-
dc.contributor.authorH M Koo-
dc.contributor.authorS H Cho-
dc.contributor.authorSang Jeon Chung-
dc.contributor.authorYong Taik Lim-
dc.contributor.authorD Kim-
dc.contributor.authorS H Yuk-
dc.date.accessioned2017-04-19T09:09:38Z-
dc.date.available2017-04-19T09:09:38Z-
dc.date.issued2008-
dc.identifier.issn0265-2048-
dc.identifier.uri10.1080/02652040701800917ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8328-
dc.description.abstractHeparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/ intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC).-
dc.publisherT&F (Taylor & Francis)-
dc.titleHeparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug-
dc.title.alternativeHeparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug-
dc.typeArticle-
dc.citation.titleJournal of Microencapsulation-
dc.citation.number2-
dc.citation.endPage110-
dc.citation.startPage106-
dc.citation.volume25-
dc.contributor.affiliatedAuthorSang Jeon Chung-
dc.contributor.affiliatedAuthorYong Taik Lim-
dc.contributor.alternativeName박화영-
dc.contributor.alternativeName오근상-
dc.contributor.alternativeName구형모-
dc.contributor.alternativeName조선항-
dc.contributor.alternativeName정상전-
dc.contributor.alternativeName임용택-
dc.contributor.alternativeName김동민-
dc.contributor.alternativeName육순홍-
dc.identifier.bibliographicCitationJournal of Microencapsulation, vol. 25, no. 2, pp. 106-110-
dc.identifier.doi10.1080/02652040701800917-
dc.subject.keywordHeparin-
dc.subject.keywordMicroparticle-
dc.subject.keywordPluronic-
dc.subject.keywordPolyvinylalcohol-
dc.subject.keywordSustained release of ionic drug-
dc.subject.localHeparin-
dc.subject.localMicroparticle-
dc.subject.localPluronic-
dc.subject.localPolyvinylalcohol-
dc.subject.localSustained release of ionic drug-
dc.description.journalClassY-
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