G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1

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dc.contributor.authorJ A Lee-
dc.contributor.authorJ E Park-
dc.contributor.authorDo Hee Lee-
dc.contributor.authorSung Goo Park-
dc.contributor.authorP K Myung-
dc.contributor.authorByoung Chul Park-
dc.contributor.authorS Cho-
dc.date.accessioned2017-04-19T09:09:39Z-
dc.date.available2017-04-19T09:09:39Z-
dc.date.issued2008-
dc.identifier.issn09509232-
dc.identifier.uri10.1038/sj.onc.1210740ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8333-
dc.description.abstractApoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase kinase kinase family, plays a critical role in mediating apoptosis signals initiated by a variety of death stimuli such as hydrogen peroxide and tumor necrosis factor-α. Owing to its critical role in inducing apoptosis, the activity of ASK1 is tightly regulated by various mechanisms such as post-translational modifications and protein-protein interactions. Here we describe the identification of G1 to S phase transition protein 1 (GSPT1), which is associated with protein translation, as a regulator of ASK1. GSPT1 interacts with ASK1 and enhances ASK1-induced apoptotic activity through the activation of caspase-3. In vitro kinase assay data show that GSPT1 enhances ASK1 autophosphorylation and its kinase activity. Cell cycle-dependent GSPT1 induction and small interfering RNA analyses show that ASK1 autophosphorylation is dependent on the expression level of endogenous GSPT1 in cells. GSPT1 inhibits the binding of ASK1 to the 14-3-3 protein, an ASK1 inhibitor, while GSPT1 has no effect on the interaction between ASK1 and TRAF2, a C-terminal-binding activator of ASK1. Thus, our results reveal a novel role of GSPT1 in the regulation of ASK1-mediated apoptosis.-
dc.publisherSpringer-Nature Pub Group-
dc.titleG1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1-
dc.title.alternativeG1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1-
dc.typeArticle-
dc.citation.titleOncogene-
dc.citation.number9-
dc.citation.endPage1305-
dc.citation.startPage1297-
dc.citation.volume27-
dc.contributor.affiliatedAuthorSung Goo Park-
dc.contributor.affiliatedAuthorByoung Chul Park-
dc.contributor.alternativeName-
dc.contributor.alternativeName박재은-
dc.contributor.alternativeName이도희-
dc.contributor.alternativeName박성구-
dc.contributor.alternativeName명평근-
dc.contributor.alternativeName박병철-
dc.contributor.alternativeName조사연-
dc.identifier.bibliographicCitationOncogene, vol. 27, no. 9, pp. 1297-1305-
dc.identifier.doi10.1038/sj.onc.1210740-
dc.subject.keywordapoptosis-
dc.subject.keywordapoptosis signal-regulating kinase 1-
dc.subject.keywordG1 to S phase transition 1-
dc.subject.keywordMitogen-activated protein kinase-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localapoptosis signal-regulating kinase 1-
dc.subject.localG1 to S phase transition 1-
dc.subject.localMitogen-activated protein kinase-
dc.subject.localMitogen activated protein kinase-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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