Synthesis and antioxidant activities of 3,5-dialkoxy-4-hydroxycinnamamides

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Title
Synthesis and antioxidant activities of 3,5-dialkoxy-4-hydroxycinnamamides
Author(s)
T S Kang; H O Jo; W K Park; Jong Pyung Kim; Y Konishi; J Y Kong; N S Park; Y S Jung
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 5, pp. 1663-1667
Publication Year
2008
Abstract
A series of 3,5-dialkoxy-4-hydroxycinnamamides 6 and 7 was synthesized, and their antioxidant activity was assessed using the thiobarbituric acid reactive substance (TBARS) assay. Interestingly, cinnamamides with longer alkoxy groups on the C-3 and C-5 positions display enhanced inhibition, and most of the compounds in the series tested exhibit excellent lipid peroxidation inhibitory activities. Some cinamamides bearing hexyloxy or 2,6-di-tert-butyl-4-methyl phenol groups have submicromolar inhibitory activities.
Keyword
4-Hydroxycinnamamideantioxidantlipid peroxidationreactive oxygen species
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2008.01.061
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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