Enhanced biomass and γ-linolenic acid production of mutant strain Arthrospira platensis

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Title
Enhanced biomass and γ-linolenic acid production of mutant strain Arthrospira platensis
Author(s)
Gang Guk Choi; M S Bae; Chi-Yong AhnHee-Mock Oh
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 18, no. 3, pp. 539-544
Publication Year
2008
Abstract
A mutant of Arthrospira platensis PCC 9108, strain M9108, obtained by mutagenesis with UV treatment, was able to mixotrophically grow in an SOT medium containing 40 g of glucose/I. The biomass and specific growth rate of strain M9108 (4.10 g/I and 0.70/d) were 1.9-fold and 1.4-fold higher, respectively, than those of the wild type (2.21 g/I and 0.58/d) under mixotrophic culture condition. In addition, when compared with the wild type, the content of γ-linolenic acid (GLA) in the mutant was increased when glucose concentration was increased. Compared with the wild type, the GLA content of the mutant was 2-fold higher in autotrophic culture and about 3-fold higher in mixotrophic culture. Thus, the mutant appears to possess more efficient facility to assimilate and metabolize glucose and to produce more GLA than its wild-type strain.
Keyword
arthrospira platensisbiomassGLAmixotrophic cultivationUVγ-linolenic acid
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Synthetic Biology and Bioengineering Research Institute > Cell Factory Research Center > 1. Journal Articles
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