VDUP1 mediates nuclear export of HIF1α via CRM1-dependent pathway

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dc.contributor.authorDaesung Shin-
dc.contributor.authorJ H Jeon-
dc.contributor.authorMi Ra Jeong-
dc.contributor.authorHyun-Woo Suh-
dc.contributor.authorS Kim-
dc.contributor.authorHyoung-Chin Kim-
dc.contributor.authorOg Sung Moon-
dc.contributor.authorYong Sung Kim-
dc.contributor.authorJin Woong Chung-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorW H Kim-
dc.contributor.authorIn Pyo Choi-
dc.date.accessioned2017-04-19T09:09:58Z-
dc.date.available2017-04-19T09:09:58Z-
dc.date.issued2008-
dc.identifier.issn0167-4889-
dc.identifier.uri10.1016/j.bbamcr.2007.10.012ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8381-
dc.description.abstractHypoxia-inducible factor 1α (HIF1α) is a critical transcriptional factor for inducing tumor metastasis, and stabilized under hypoxia but degraded by von Hippel-Lindau protein (pVHL) under normoxia. For the maximal degradation of HIF1α, it must be exported to the cytoplasm via an unidentified transporter. Here, we demonstrate that vitamin D3 up-regulated protein 1 (VDUP1) associates with the β-domain of pVHL and enhances the interaction between pVHL and HIF1α to promote the nuclear export and degradation of HIF1α hypoxia-independently. Blocking of VDUP1 translocation either by leptomycin B or by nuclear export signal mutation inhibited the nuclear export of pVHL/HIF1α and relieved the destabilization of HIF1α. VDUP1 suppressed cell invasiveness and tumor metastasis, which were also recovered by blocking of nuclear export. Taken together, these findings indicate that VDUP1 is a novel tumor suppressor which mediates the nuclear export of pVHL/HIF1α complex to destabilize HIF1α.-
dc.publisherElsevier-
dc.titleVDUP1 mediates nuclear export of HIF1α via CRM1-dependent pathway-
dc.title.alternativeVDUP1 mediates nuclear export of HIF1α via CRM1-dependent pathway-
dc.typeArticle-
dc.citation.titleBiochimica et Biophysica Acta-Molecular Cell Research-
dc.citation.number5-
dc.citation.endPage848-
dc.citation.startPage838-
dc.citation.volume1783-
dc.contributor.affiliatedAuthorDaesung Shin-
dc.contributor.affiliatedAuthorMi Ra Jeong-
dc.contributor.affiliatedAuthorHyun-Woo Suh-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.affiliatedAuthorOg Sung Moon-
dc.contributor.affiliatedAuthorYong Sung Kim-
dc.contributor.affiliatedAuthorJin Woong Chung-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeName신대성-
dc.contributor.alternativeName전준호-
dc.contributor.alternativeName정미라-
dc.contributor.alternativeName서현우-
dc.contributor.alternativeName김세일-
dc.contributor.alternativeName김형진-
dc.contributor.alternativeName문옥성-
dc.contributor.alternativeName김용성-
dc.contributor.alternativeName정진웅-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName김우호-
dc.contributor.alternativeName최인표-
dc.identifier.bibliographicCitationBiochimica et Biophysica Acta-Molecular Cell Research, vol. 1783, no. 5, pp. 838-848-
dc.identifier.doi10.1016/j.bbamcr.2007.10.012-
dc.subject.keywordCRM1-
dc.subject.keywordHIF1α-
dc.subject.keywordpVHL-
dc.subject.keywordtransport-
dc.subject.keywordVDUP1-
dc.subject.localCRM1-
dc.subject.localHif1α-
dc.subject.localHIF-1α-
dc.subject.localHIF1α-
dc.subject.localpVHL-
dc.subject.localtransport-
dc.subject.localTransport-
dc.subject.localVDUP1-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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