The regulation of NK cell function and development

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dc.contributor.authorJin Woong Chung-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorIn Pyo Choi-
dc.description.abstractNK cells are the lymphocytes that are differentiated from hematopoietic stem cells in bone marrow (BM) through sequential acquisition of functional receptors. They are one of the critical components of innate immune system. The process of NK differentiation involves a variety of factors such as cytokines, membrane factors, and transcription factors in addition to BM microenvironment. NK cells express their own activating and inhibitory receptors. The cytolytic functions of NK cells against target cells are determined by the balance between theses activating and inhibitory receptors. NK cells discriminate self from non-self by MHC class I-binding inhibitory receptor. Once NK cell inhibitory receptors bound to their MHC class I-ligand, the target cells are protected from NK cell-mediated cytotoxicity. The cytolytic effector functions as well as the characteristic surface phenotypes of NK cells are acquired during the differentiation process. NK cells are emerging to apply as therapeutic agents against a variety of cancers by manipulating differentiation processes and intrinsic activities of the NK cell.-
dc.publisherFrontiers In Bioscience Inc-
dc.titleThe regulation of NK cell function and development-
dc.title.alternativeThe regulation of NK cell function and development-
dc.citation.titleFrontiers in Bioscience-Landmark-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.identifier.bibliographicCitationFrontiers in Bioscience-Landmark, vol. 13, pp. 6432-6442-
dc.subject.keywordHematopoietic stem cells-
dc.subject.keywordNatural killer development-
dc.subject.keywordNK cell activity-
dc.subject.keywordNK cell therapy-
dc.subject.localHematopoietic stem cells-
dc.subject.localHematopoietic stem cell-
dc.subject.localNatural killer development-
dc.subject.localNK cell activity-
dc.subject.localNK cell therapy-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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