Chitin synthase 2 inhibitory activity of 0-methyl pisiferic acid and 8,20-dihydroxy-9(11),13-abietadien-12-one, isolated from Chamaecyparis pisifera = 화백으로부터 분리한 0-methyl pisiferic acid와 8,20-dihydroxy-9(11),13-abietadien-12-one 화합물의 키틴

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dc.contributor.authorTae-Hoon Kang-
dc.contributor.authorE I Hwang-
dc.contributor.authorBong Sik Yun-
dc.contributor.authorC S Shin-
dc.contributor.authorSung Uk Kim-
dc.date.accessioned2017-04-19T09:09:59Z-
dc.date.available2017-04-19T09:09:59Z-
dc.date.issued2008-
dc.identifier.issn09186158-
dc.identifier.uri10.1248/bpb.31.755ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8388-
dc.description.abstractIn the course of search for potent chitin synthase inhibitors from plant extracts, the chitin synthase 2 inhibitors, O-methyl pisiferic acid and 8,20-dihydroxy-9(11),13-abietadien-12-one which have diterpene skeleton, were isolated from the leaves of Chamaecyparis pisifera. These compounds inhibited chitin synthase 2 of Saccharomyces cerevisiae with the IC50 values of 5.8 and 226.4 μM, respectively. Especially, O-methyl pisiferic acid showed 15.3-fold stronger inhibitory activity than polyoxin D (IC50=88.6 μM), a well-known chitin synthase inhibitor. These compounds exhibited weaker inhibitory activities against chitin synthase 1 than chitin synthase 2, whereas it showed no inhibitory activity for chitin synthase 3. The compound exhibited mixed competitive inhibition with respect to UDP-N-acetyl-D-glucosamine as substrate (Ki=5 μM). These results indicated that O-methyl pisiferic acid is a specific inhibitor of chitin synthase 2. The compound also inhibited chitin synthase 1 of Candida albicans, which represents analogues to chitin synthase 2 of S. cerevisiae, with an IC50 of 75.6 μM, which represents 1.8-fold weaker activity than that of polyoxin D. Although O-methyl pisiferic acid has been reported for antibacterial and insecticidal activities, the present study is the first report on its inhibitory activity against chitin synthase 2.-
dc.publisherPharmaceutical Soc Japan-
dc.titleChitin synthase 2 inhibitory activity of 0-methyl pisiferic acid and 8,20-dihydroxy-9(11),13-abietadien-12-one, isolated from Chamaecyparis pisifera = 화백으로부터 분리한 0-methyl pisiferic acid와 8,20-dihydroxy-9(11),13-abietadien-12-one 화합물의 키틴-
dc.title.alternativeChitin synthase 2 inhibitory activity of 0-methyl pisiferic acid and 8,20-dihydroxy-9(11),13-abietadien-12-one, isolated from Chamaecyparis pisifera-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number4-
dc.citation.endPage759-
dc.citation.startPage755-
dc.citation.volume31-
dc.contributor.alternativeName강태훈-
dc.contributor.alternativeName황의일-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName신철수-
dc.contributor.alternativeName김성욱-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 31, no. 4, pp. 755-759-
dc.identifier.doi10.1248/bpb.31.755-
dc.subject.keywordAntifungal activity-
dc.subject.keywordChamaecyparis pisifera-
dc.subject.keywordChitin synthase inhibitor-
dc.subject.keywordO-methyl pisiferic acid-
dc.subject.localAntifungal activity-
dc.subject.localChamaecyparis pisifera-
dc.subject.localChitin synthase inhibitor-
dc.subject.localO-methyl pisiferic acid-
dc.description.journalClassY-
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