DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam Hui Yim | - |
dc.contributor.author | E I Hwang | - |
dc.contributor.author | Bong Sik Yun | - |
dc.contributor.author | K D Park | - |
dc.contributor.author | Jae Sun Moon | - |
dc.contributor.author | S H Lee | - |
dc.contributor.author | N D Sung | - |
dc.contributor.author | Sung Uk Kim | - |
dc.date.accessioned | 2017-04-19T09:10:00Z | - |
dc.date.available | 2017-04-19T09:10:00Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | 10.1248/bpb.31.1041 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8392 | - |
dc.description.abstract | A novel sesquiterpene furan compound CJ-01 was isolated from the methanol extract of the whole plant of Chloranthus japonicus SIEB. by monitoring the inhibitory activity of chitin synthase 2 from Saccharomyces cerevisiae. Based on spectroscopic analysis, the structure of compound CJ-01 was determined as 3,4,8a-trimethyl-4a,7,8,8a-tetrahydro-4a-naphto[2,3-b]furan-9-one. The compound inhibited chitin synthase 2 of Saccharomyces cerevisiae in a dose-dependent manner with an IC50 of 39.6 μg/ml, whereas it exhibited no inhibitory activities against chitin synthase 1 and 3 of S. cerevisiae up to 280 μg/ml. CJ-01 has 1.7-fold stronger inhibitory activity than polyoxin D (IC50=70 μg/ml), a well-known chitin synthase inhibitor. These results indicate that the compound is a specific inhibitor of chitin synthase 2 from S. cerevisiae. In addition, CJ-01 showed antifungal activities against various human and phytopathogenic fungi. Therefore, the compound might be an interesting lead to develop effective antifungal agents. | - |
dc.publisher | Pharmaceutical Soc Japan | - |
dc.title | Sesquiterpene furan compound CJ-01, a novel chitin synthase 2 inhibitor from Chloranthus japonicus SIEB | - |
dc.title.alternative | Sesquiterpene furan compound CJ-01, a novel chitin synthase 2 inhibitor from Chloranthus japonicus SIEB | - |
dc.type | Article | - |
dc.citation.title | Biological & Pharmaceutical Bulletin | - |
dc.citation.number | 5 | - |
dc.citation.endPage | 1044 | - |
dc.citation.startPage | 1041 | - |
dc.citation.volume | 31 | - |
dc.contributor.affiliatedAuthor | Nam Hui Yim | - |
dc.contributor.affiliatedAuthor | Bong Sik Yun | - |
dc.contributor.affiliatedAuthor | Jae Sun Moon | - |
dc.contributor.affiliatedAuthor | Sung Uk Kim | - |
dc.contributor.alternativeName | 임남희 | - |
dc.contributor.alternativeName | 황의일 | - |
dc.contributor.alternativeName | 윤봉식 | - |
dc.contributor.alternativeName | 박기덕 | - |
dc.contributor.alternativeName | 문제선 | - |
dc.contributor.alternativeName | 이상한 | - |
dc.contributor.alternativeName | 성낙도 | - |
dc.contributor.alternativeName | 김성욱 | - |
dc.identifier.bibliographicCitation | Biological & Pharmaceutical Bulletin, vol. 31, no. 5, pp. 1041-1044 | - |
dc.identifier.doi | 10.1248/bpb.31.1041 | - |
dc.subject.keyword | antifungal activity | - |
dc.subject.keyword | chitin synthase 2 inhibitor | - |
dc.subject.keyword | chloranthus japonicus | - |
dc.subject.keyword | fungal cell wall | - |
dc.subject.keyword | sesquiterpene furan compound CJ-01 | - |
dc.subject.local | Antifungal activity | - |
dc.subject.local | Anti-fungal activity | - |
dc.subject.local | antifungal activity | - |
dc.subject.local | chitin synthase 2 inhibitor | - |
dc.subject.local | Chitin synthase II | - |
dc.subject.local | chitin synthase Ⅱ inhibitors | - |
dc.subject.local | chitin synthase II inhibitor | - |
dc.subject.local | chitin synthase Ⅱ | - |
dc.subject.local | Chloranthus japonicus | - |
dc.subject.local | chloranthus japonicus | - |
dc.subject.local | Fungal cell walls | - |
dc.subject.local | fungal cell wall | - |
dc.subject.local | sesquiterpene furan compound CJ-01 | - |
dc.description.journalClass | Y | - |
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