Sesquiterpene furan compound CJ-01, a novel chitin synthase 2 inhibitor from Chloranthus japonicus SIEB

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dc.contributor.authorNam Hui Yim-
dc.contributor.authorE I Hwang-
dc.contributor.authorBong Sik Yun-
dc.contributor.authorK D Park-
dc.contributor.authorJae Sun Moon-
dc.contributor.authorS H Lee-
dc.contributor.authorN D Sung-
dc.contributor.authorSung Uk Kim-
dc.date.accessioned2017-04-19T09:10:00Z-
dc.date.available2017-04-19T09:10:00Z-
dc.date.issued2008-
dc.identifier.issn0918-6158-
dc.identifier.uri10.1248/bpb.31.1041ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8392-
dc.description.abstractA novel sesquiterpene furan compound CJ-01 was isolated from the methanol extract of the whole plant of Chloranthus japonicus SIEB. by monitoring the inhibitory activity of chitin synthase 2 from Saccharomyces cerevisiae. Based on spectroscopic analysis, the structure of compound CJ-01 was determined as 3,4,8a-trimethyl-4a,7,8,8a-tetrahydro-4a-naphto[2,3-b]furan-9-one. The compound inhibited chitin synthase 2 of Saccharomyces cerevisiae in a dose-dependent manner with an IC50 of 39.6 μg/ml, whereas it exhibited no inhibitory activities against chitin synthase 1 and 3 of S. cerevisiae up to 280 μg/ml. CJ-01 has 1.7-fold stronger inhibitory activity than polyoxin D (IC50=70 μg/ml), a well-known chitin synthase inhibitor. These results indicate that the compound is a specific inhibitor of chitin synthase 2 from S. cerevisiae. In addition, CJ-01 showed antifungal activities against various human and phytopathogenic fungi. Therefore, the compound might be an interesting lead to develop effective antifungal agents.-
dc.publisherPharmaceutical Soc Japan-
dc.titleSesquiterpene furan compound CJ-01, a novel chitin synthase 2 inhibitor from Chloranthus japonicus SIEB-
dc.title.alternativeSesquiterpene furan compound CJ-01, a novel chitin synthase 2 inhibitor from Chloranthus japonicus SIEB-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number5-
dc.citation.endPage1044-
dc.citation.startPage1041-
dc.citation.volume31-
dc.contributor.affiliatedAuthorNam Hui Yim-
dc.contributor.affiliatedAuthorBong Sik Yun-
dc.contributor.affiliatedAuthorJae Sun Moon-
dc.contributor.affiliatedAuthorSung Uk Kim-
dc.contributor.alternativeName임남희-
dc.contributor.alternativeName황의일-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName박기덕-
dc.contributor.alternativeName문제선-
dc.contributor.alternativeName이상한-
dc.contributor.alternativeName성낙도-
dc.contributor.alternativeName김성욱-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 31, no. 5, pp. 1041-1044-
dc.identifier.doi10.1248/bpb.31.1041-
dc.subject.keywordantifungal activity-
dc.subject.keywordchitin synthase 2 inhibitor-
dc.subject.keywordchloranthus japonicus-
dc.subject.keywordfungal cell wall-
dc.subject.keywordsesquiterpene furan compound CJ-01-
dc.subject.localAntifungal activity-
dc.subject.localAnti-fungal activity-
dc.subject.localantifungal activity-
dc.subject.localchitin synthase 2 inhibitor-
dc.subject.localChitin synthase II-
dc.subject.localchitin synthase Ⅱ inhibitors-
dc.subject.localchitin synthase II inhibitor-
dc.subject.localchitin synthase Ⅱ-
dc.subject.localChloranthus japonicus-
dc.subject.localchloranthus japonicus-
dc.subject.localFungal cell walls-
dc.subject.localfungal cell wall-
dc.subject.localsesquiterpene furan compound CJ-01-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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