DC Field | Value | Language |
---|---|---|
dc.contributor.author | J S Kim | - |
dc.contributor.author | S I Lee | - |
dc.contributor.author | H W Park | - |
dc.contributor.author | J H Yang | - |
dc.contributor.author | T Y Shin | - |
dc.contributor.author | Y C Kim | - |
dc.contributor.author | N I Baek | - |
dc.contributor.author | S H Kim | - |
dc.contributor.author | S U Choi | - |
dc.contributor.author | Byoung-Mog Kwon | - |
dc.contributor.author | K H Leem | - |
dc.contributor.author | M Y Jung | - |
dc.contributor.author | D K Kim | - |
dc.date.accessioned | 2017-04-19T09:10:01Z | - |
dc.date.available | 2017-04-19T09:10:01Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | 10.1007/s12272-001-1172-y | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8397 | - |
dc.description.abstract | Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53-/-, c-myc, K-ras) and C2 (genotype: p53 -/-, c-myc, Akt), with ED50 values of 0.58 μM (C1) and 10.7 μM (C2). | - |
dc.publisher | Pharmaceutical Soc Korea | - |
dc.title | Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe = Zingiber officinale Roscoe에서 분리한 생리활성 물질 | - |
dc.title.alternative | Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe | - |
dc.type | Article | - |
dc.citation.title | Archives of Pharmacal Research | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 418 | - |
dc.citation.startPage | 415 | - |
dc.citation.volume | 31 | - |
dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
dc.contributor.alternativeName | 김주신 | - |
dc.contributor.alternativeName | 이사임 | - |
dc.contributor.alternativeName | 박혜원 | - |
dc.contributor.alternativeName | 양재헌 | - |
dc.contributor.alternativeName | 신태용 | - |
dc.contributor.alternativeName | 김연철 | - |
dc.contributor.alternativeName | 백남인 | - |
dc.contributor.alternativeName | 김성훈 | - |
dc.contributor.alternativeName | 최상운 | - |
dc.contributor.alternativeName | 권병목 | - |
dc.contributor.alternativeName | 임강현 | - |
dc.contributor.alternativeName | 정문응 | - |
dc.contributor.alternativeName | 김대근 | - |
dc.identifier.bibliographicCitation | Archives of Pharmacal Research, vol. 31, no. 4, pp. 415-418 | - |
dc.identifier.doi | 10.1007/s12272-001-1172-y | - |
dc.subject.keyword | Cell proliferation | - |
dc.subject.keyword | Cytotoxicity | - |
dc.subject.keyword | Gingerol | - |
dc.subject.keyword | Shogaol | - |
dc.subject.keyword | Zingiber officinale | - |
dc.subject.keyword | Zingiberaceae | - |
dc.subject.local | Cell proliferation | - |
dc.subject.local | cell proliferation | - |
dc.subject.local | Cytotoxicity | - |
dc.subject.local | cytotoxicity | - |
dc.subject.local | Gingerol | - |
dc.subject.local | Gingerols | - |
dc.subject.local | Shogaol | - |
dc.subject.local | Shogaols | - |
dc.subject.local | Zingiber officinale | - |
dc.subject.local | Zingiberaceae | - |
dc.description.journalClass | Y | - |
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