Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe = Zingiber officinale Roscoe에서 분리한 생리활성 물질

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dc.contributor.authorJ S Kim-
dc.contributor.authorS I Lee-
dc.contributor.authorH W Park-
dc.contributor.authorJ H Yang-
dc.contributor.authorT Y Shin-
dc.contributor.authorY C Kim-
dc.contributor.authorN I Baek-
dc.contributor.authorS H Kim-
dc.contributor.authorS U Choi-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorK H Leem-
dc.contributor.authorM Y Jung-
dc.contributor.authorD K Kim-
dc.date.accessioned2017-04-19T09:10:01Z-
dc.date.available2017-04-19T09:10:01Z-
dc.date.issued2008-
dc.identifier.issn0253-6269-
dc.identifier.uri10.1007/s12272-001-1172-yko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8397-
dc.description.abstractFive compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53-/-, c-myc, K-ras) and C2 (genotype: p53 -/-, c-myc, Akt), with ED50 values of 0.58 μM (C1) and 10.7 μM (C2).-
dc.publisherPharmaceutical Soc Korea-
dc.titleCytotoxic components from the dried rhizomes of Zingiber officinale Roscoe = Zingiber officinale Roscoe에서 분리한 생리활성 물질-
dc.title.alternativeCytotoxic components from the dried rhizomes of Zingiber officinale Roscoe-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number4-
dc.citation.endPage418-
dc.citation.startPage415-
dc.citation.volume31-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName김주신-
dc.contributor.alternativeName이사임-
dc.contributor.alternativeName박혜원-
dc.contributor.alternativeName양재헌-
dc.contributor.alternativeName신태용-
dc.contributor.alternativeName김연철-
dc.contributor.alternativeName백남인-
dc.contributor.alternativeName김성훈-
dc.contributor.alternativeName최상운-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName임강현-
dc.contributor.alternativeName정문응-
dc.contributor.alternativeName김대근-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 31, no. 4, pp. 415-418-
dc.identifier.doi10.1007/s12272-001-1172-y-
dc.subject.keywordCell proliferation-
dc.subject.keywordCytotoxicity-
dc.subject.keywordGingerol-
dc.subject.keywordShogaol-
dc.subject.keywordZingiber officinale-
dc.subject.keywordZingiberaceae-
dc.subject.localCell proliferation-
dc.subject.localcell proliferation-
dc.subject.localCytotoxicity-
dc.subject.localcytotoxicity-
dc.subject.localGingerol-
dc.subject.localGingerols-
dc.subject.localShogaol-
dc.subject.localShogaols-
dc.subject.localZingiber officinale-
dc.subject.localZingiberaceae-
dc.description.journalClassY-
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