The mechanism of anti-platelet activity of davallialactone: Involvement of intracellular calcium ions, extracellular signal-regulated kinase 2 and p38 mitogen-activated protein kinase

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dc.contributor.authorS D Kim-
dc.contributor.authorIn Kyoung Lee-
dc.contributor.authorW M Lee-
dc.contributor.authorJ Y Cho-
dc.contributor.authorH J Park-
dc.contributor.authorJ W Oh-
dc.contributor.authorS C Park-
dc.contributor.authorS K Kim-
dc.contributor.authorY S Kwak-
dc.contributor.authorBong Sik Yun-
dc.contributor.authorM H Rhee-
dc.date.accessioned2017-04-19T09:10:02Z-
dc.date.available2017-04-19T09:10:02Z-
dc.date.issued2008-
dc.identifier.issn0014-2999-
dc.identifier.uri10.1016/j.ejphar.2008.02.008ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8403-
dc.description.abstractThis study was designed to investigate the effect of davallialactone, which was isolated from the mushroom Inonotus xeranticus, on platelet aggregation induced by collagen, thrombin and ADP. We found that davallialactone dose-dependently inhibited platelet aggregation that was stimulated either by collagen (2.5 μg/ml), a potent ligand of integrin α2β1 and glycoprotein VI, or by thrombin (0.1U/ml), a potent agonist of the protease-activated receptors (PARs) PAR1 and PAR3. In addition, davallialactone inhibited platelet aggregation induced by ADP, an agonist of P2Y receptor. To understand the mechanism of anti-platelet activity, we determined whether davallialactone affected the downstream signaling in collagen-activated platelets. Using the fura-2/AM fluorometric assay, we found that davallialactone dose-dependently inhibited intracellular calcium concentration levels ([Ca2+]i). Moreover, davallialactone inhibited the phosphorylation of extracellular signal-regulated protein kinase (ERK)-2 and p38 mitogen-activated protein kinase (MAPK), in a dose-dependent manner. The tyrosine phosphorylation of 60 and 85kDa proteins, which were activated by collagen, were differentially inhibited by davallialactone. Taken together, these data suggest that davallialactone may have potential anti-platelet aggregation activity via suppression of intracellular downstream signaling pathways.-
dc.publisherElsevier-
dc.titleThe mechanism of anti-platelet activity of davallialactone: Involvement of intracellular calcium ions, extracellular signal-regulated kinase 2 and p38 mitogen-activated protein kinase-
dc.title.alternativeThe mechanism of anti-platelet activity of davallialactone: Involvement of intracellular calcium ions, extracellular signal-regulated kinase 2 and p38 mitogen-activated protein kinase-
dc.typeArticle-
dc.citation.titleEuropean Journal of Pharmacology-
dc.citation.number2-
dc.citation.endPage367-
dc.citation.startPage361-
dc.citation.volume584-
dc.contributor.affiliatedAuthorIn Kyoung Lee-
dc.contributor.affiliatedAuthorBong Sik Yun-
dc.contributor.alternativeName김성대-
dc.contributor.alternativeName이인경-
dc.contributor.alternativeName이희민-
dc.contributor.alternativeName조재열-
dc.contributor.alternativeName박화진-
dc.contributor.alternativeName오재욱-
dc.contributor.alternativeName박승춘-
dc.contributor.alternativeName김상근-
dc.contributor.alternativeName곽이성-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName이만희-
dc.identifier.bibliographicCitationEuropean Journal of Pharmacology, vol. 584, no. 2, pp. 361-367-
dc.identifier.doi10.1016/j.ejphar.2008.02.008-
dc.subject.keyword[Ca2+]i-
dc.subject.keywordADP-
dc.subject.keywordcollagen-
dc.subject.keyworddavallialactone-
dc.subject.keywordERK2-
dc.subject.keywordinonotus xeranticus-
dc.subject.keywordp38 MAPK-
dc.subject.keywordplatelet aggregation-
dc.subject.keywordthrombin-
dc.subject.local[Ca2+]i-
dc.subject.localADP-
dc.subject.localCollagen-
dc.subject.localcollagen-
dc.subject.localDavallialactone-
dc.subject.localdavallialactone-
dc.subject.localERK2-
dc.subject.localinonotus xeranticus-
dc.subject.localInonotus xeranticus-
dc.subject.localp38 MAP kinase-
dc.subject.localp38 mitogen-activated protein kinase (p38 MARK)-
dc.subject.localP38 MAPK-
dc.subject.localp38 mitogen-activated protein kinase-
dc.subject.localp38 MAPK-
dc.subject.localp38MAPK-
dc.subject.localPlatelet aggregation-
dc.subject.localplatelet aggregation-
dc.subject.localthrombin-
dc.subject.localThrombin-
dc.description.journalClassY-
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