Hypoxia-inducible factor-1 and nuclear factor-κB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia

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dc.contributor.authorC Z Wu-
dc.contributor.authorS S Hong-
dc.contributor.authorX F Cai-
dc.contributor.authorN T Dat-
dc.contributor.authorJ X Nan-
dc.contributor.authorB Y Hwang-
dc.contributor.authorJung Joon Lee-
dc.contributor.authorD Lee-
dc.date.accessioned2017-04-19T09:10:02Z-
dc.date.available2017-04-19T09:10:02Z-
dc.date.issued2008-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2008.03.028ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8405-
dc.description.abstractTwo new meroterpenoids, 12,13-dihydro-12,13-dihydroxybakuchiol (2) and (12′S)-bisbakuchiol C (3), were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). The structures of 2 and 3 were elucidated by spectroscopic and chemical methods. Six meroterpenoids isolated from P. corylifolia and three semi-synthetic analogues were evaluated for HIF-1 and NF-κB inhibition, and O-methyl and O-ethylbakuchiols (6 and 7) inhibited HIF-1 and NF-κB activation without significantly decreasing the viability of the AGS and HeLa cells, respectively.-
dc.publisherElsevier-
dc.titleHypoxia-inducible factor-1 and nuclear factor-κB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia-
dc.title.alternativeHypoxia-inducible factor-1 and nuclear factor-κB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number8-
dc.citation.endPage2623-
dc.citation.startPage2619-
dc.citation.volume18-
dc.contributor.affiliatedAuthorJung Joon Lee-
dc.contributor.alternativeNameWu-
dc.contributor.alternativeName홍성수-
dc.contributor.alternativeNameCai-
dc.contributor.alternativeNameDat-
dc.contributor.alternativeNameNan-
dc.contributor.alternativeName황방연-
dc.contributor.alternativeName이정준-
dc.contributor.alternativeName이동호-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 18, no. 8, pp. 2619-2623-
dc.identifier.doi10.1016/j.bmcl.2008.03.028-
dc.subject.keywordFabaceae-
dc.subject.keywordHypoxia-inducible factor-1-
dc.subject.keywordMeroterpenoids-
dc.subject.keywordNuclear factor-κB-
dc.subject.keywordPsoralea corylifolia-
dc.subject.localfabaceae-
dc.subject.localFabaceae-
dc.subject.localhypoxia-inducible factor-1 (HIF-1)-
dc.subject.localHypoxiainducible factor 1-
dc.subject.localHypoxia-inducible factor-1-
dc.subject.localMeroterpenoid-
dc.subject.localMeroterpenoids-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.subject.localPsoralea corylifolia L.-
dc.subject.localPsoralea corylifolia-
dc.description.journalClassY-
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