A diterpenoid acanthoic acid from Acanthopanax koreanum protects against D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice

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dc.contributor.authorJ X Nan-
dc.contributor.authorX J Jin-
dc.contributor.authorL H Lian-
dc.contributor.authorX F Cai-
dc.contributor.authorY Z Jiang-
dc.contributor.authorH R Jin-
dc.contributor.authorJung Joon Lee-
dc.date.accessioned2017-04-19T09:10:04Z-
dc.date.available2017-04-19T09:10:04Z-
dc.date.issued2008-
dc.identifier.issn0918-6158-
dc.identifier.uri10.1248/bpb.31.738ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8407-
dc.description.abstractThe hepatoprotective effects of a diterpenoid acanthoic acid isolated from Acanthopanax koreanum NAKAI were evaluated in a D-galactosamine/ lipopolysaccharide-induced fulminant hepatic failure mouse model. Mice were pretreated orally with acanthoic acid 12 and 1 h before intraperitoneal injection of D-galactosamine and lipopolysaccharide. Pretreatment with the compound markedly reduced lethal liver injury in experimental animals. The effects were likely associated with a significant decrease in serum tumor necrosis factor (TNF)-α levels, which are correlated not only with those of alanine aminotransferase and aspartate aminotransferase but also with the reduced number of apoptotic hepatocytes in the liver as confirmed using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method and DNA fragmentation assay. These results suggest that acanthoic acid protects against D-galactosamine/lipopolysaccharide-induced fulminant liver failure at least in part by a mechanism associated with the down-regulation of TNF-α secretion.-
dc.publisherPharmaceutical Soc Japan-
dc.titleA diterpenoid acanthoic acid from Acanthopanax koreanum protects against D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice-
dc.title.alternativeA diterpenoid acanthoic acid from Acanthopanax koreanum protects against D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number4-
dc.citation.endPage742-
dc.citation.startPage738-
dc.citation.volume31-
dc.contributor.affiliatedAuthorJung Joon Lee-
dc.contributor.alternativeNameNan-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeNameLian-
dc.contributor.alternativeNameCai-
dc.contributor.alternativeNameJiang-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName이정준-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 31, no. 4, pp. 738-742-
dc.identifier.doi10.1248/bpb.31.738-
dc.subject.keywordAcanthoic acid-
dc.subject.keywordAcanthopanax koreanum-
dc.subject.keywordApoptosis-
dc.subject.keywordFulminant hepatitis-
dc.subject.keywordTumor necrosis factor-α-
dc.subject.localAcanthoic acid-
dc.subject.localAcanthopanax koreanum-
dc.subject.localacanthopanax koreanum-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localFulminant hepatitis-
dc.subject.localfulminant hepatitis-
dc.subject.localTumor necrosis fa tor-α-
dc.subject.localTNFα-
dc.subject.localTumor necrosis factor (TNF)-α-
dc.subject.localTnf-α-
dc.subject.localTNF-a-
dc.subject.localTNF-alpha-
dc.subject.localTumor necrosis factor-α-
dc.subject.localtumor necrosis factor-alpha-
dc.subject.localTNFa-
dc.subject.localTumor necrosis factor alpha-
dc.subject.localTumor necrosis factor-alpha-
dc.subject.localTNF-α-
dc.subject.localtumor necrosis factor-α-
dc.description.journalClassY-
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