Human acyl-CoA: Cholesterol acyltransferase (hACAT) inhibitory activities of triterpenoids from roots of Glycine max (L.) Merr.

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dc.contributor.authorJ H Lee-
dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorB W Lee-
dc.contributor.authorJ H Kim-
dc.contributor.authorWoo Song Lee-
dc.contributor.authorY D Park-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorK H Park-
dc.date.accessioned2017-04-19T09:10:10Z-
dc.date.available2017-04-19T09:10:10Z-
dc.date.issued2008-
dc.identifier.issn02532964-
dc.identifier.uri10.5012/bkcs.2008.29.3.615ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8410-
dc.description.abstractEight triterpenoids, six lanostanes 1-6, one lupenane 7, and one oleanane 8, were isolated by bioactivity-guided fractionation of the ethylacetate extract from roots of Glycine max (L.) Merr. All isolated compounds were examined for their inhibitory activities against human ACAT-1 (hACAT-1) and human ACAT-2 (hACAT-2). Among them, three triterpenoids showed potent hACAT inhibitory activities, (24R)-ethylcholest-5-ene-3,7-diol (1) and 3β -hydroxylup-20(29)-en-28-oic acid (7) exhibited more potent inhibitory activity against hACAT-1 (1: IC50 = 25.0 ± 1.2 and 7: IC50 = 11.5 ± 0.4 μM) than hACAT-2 (1: IC50 = 102.0 ± 5.4 and 7: IC50 = 33.9 ± 3.7 αM), respectively. Interestingly, 5α ,8α -epidioxy-24(R)-methylcholesta-6,22-diene- 3β-ol (4) has proven to be a specific inhibitor against hACAT-1 (IC 50 = 38.7 ± 0.8 μM) compared to hACAT-2 (IC50 > 200). In conclusion, this is the first study to demonstrate that triterpenoids of G. max have potent inhibitory activities against hACAT-1 and hACAT-2.-
dc.publisherWiley-
dc.titleHuman acyl-CoA: Cholesterol acyltransferase (hACAT) inhibitory activities of triterpenoids from roots of Glycine max (L.) Merr.-
dc.title.alternativeHuman acyl-CoA: Cholesterol acyltransferase (hACAT) inhibitory activities of triterpenoids from roots of Glycine max (L.) Merr.-
dc.typeArticle-
dc.citation.titleBulletin of Korean Chemical Society-
dc.citation.number3-
dc.citation.endPage619-
dc.citation.startPage615-
dc.citation.volume29-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName이진환-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeName이병원-
dc.contributor.alternativeName김진효-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeName박용대-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName박기훈-
dc.identifier.bibliographicCitationBulletin of Korean Chemical Society, vol. 29, no. 3, pp. 615-619-
dc.identifier.doi10.5012/bkcs.2008.29.3.615-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordGlycine max-
dc.subject.keywordHuman acyl-coA: cholesterol acytransferase (hACAT)-
dc.subject.keywordRoot-
dc.subject.keywordTriterpenoid-
dc.subject.localAtherosclerosis-
dc.subject.localGlycine max-
dc.subject.localHuman acyl-coA: cholesterol acytransferase (hACAT)-
dc.subject.localRoot-
dc.subject.localTriterpenoid-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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