DC Field | Value | Language |
---|---|---|
dc.contributor.author | J H Lee | - |
dc.contributor.author | Young Bae Ryu | - |
dc.contributor.author | B W Lee | - |
dc.contributor.author | J H Kim | - |
dc.contributor.author | Woo Song Lee | - |
dc.contributor.author | Y D Park | - |
dc.contributor.author | Tae Sook Jeong | - |
dc.contributor.author | K H Park | - |
dc.date.accessioned | 2017-04-19T09:10:10Z | - |
dc.date.available | 2017-04-19T09:10:10Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | 10.5012/bkcs.2008.29.3.615 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8410 | - |
dc.description.abstract | Eight triterpenoids, six lanostanes 1-6, one lupenane 7, and one oleanane 8, were isolated by bioactivity-guided fractionation of the ethylacetate extract from roots of Glycine max (L.) Merr. All isolated compounds were examined for their inhibitory activities against human ACAT-1 (hACAT-1) and human ACAT-2 (hACAT-2). Among them, three triterpenoids showed potent hACAT inhibitory activities, (24R)-ethylcholest-5-ene-3,7-diol (1) and 3β -hydroxylup-20(29)-en-28-oic acid (7) exhibited more potent inhibitory activity against hACAT-1 (1: IC50 = 25.0 ± 1.2 and 7: IC50 = 11.5 ± 0.4 μM) than hACAT-2 (1: IC50 = 102.0 ± 5.4 and 7: IC50 = 33.9 ± 3.7 αM), respectively. Interestingly, 5α ,8α -epidioxy-24(R)-methylcholesta-6,22-diene- 3β-ol (4) has proven to be a specific inhibitor against hACAT-1 (IC 50 = 38.7 ± 0.8 μM) compared to hACAT-2 (IC50 > 200). In conclusion, this is the first study to demonstrate that triterpenoids of G. max have potent inhibitory activities against hACAT-1 and hACAT-2. | - |
dc.publisher | Wiley | - |
dc.title | Human acyl-CoA: Cholesterol acyltransferase (hACAT) inhibitory activities of triterpenoids from roots of Glycine max (L.) Merr. | - |
dc.title.alternative | Human acyl-CoA: Cholesterol acyltransferase (hACAT) inhibitory activities of triterpenoids from roots of Glycine max (L.) Merr. | - |
dc.type | Article | - |
dc.citation.title | Bulletin of Korean Chemical Society | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 619 | - |
dc.citation.startPage | 615 | - |
dc.citation.volume | 29 | - |
dc.contributor.affiliatedAuthor | Young Bae Ryu | - |
dc.contributor.affiliatedAuthor | Woo Song Lee | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.alternativeName | 이진환 | - |
dc.contributor.alternativeName | 류영배 | - |
dc.contributor.alternativeName | 이병원 | - |
dc.contributor.alternativeName | 김진효 | - |
dc.contributor.alternativeName | 이우송 | - |
dc.contributor.alternativeName | 박용대 | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.contributor.alternativeName | 박기훈 | - |
dc.identifier.bibliographicCitation | Bulletin of Korean Chemical Society, vol. 29, no. 3, pp. 615-619 | - |
dc.identifier.doi | 10.5012/bkcs.2008.29.3.615 | - |
dc.subject.keyword | Atherosclerosis | - |
dc.subject.keyword | Glycine max | - |
dc.subject.keyword | Human acyl-coA: cholesterol acytransferase (hACAT) | - |
dc.subject.keyword | Root | - |
dc.subject.keyword | Triterpenoid | - |
dc.subject.local | atherosclerosis | - |
dc.subject.local | Atherosclerosis | - |
dc.subject.local | atheroclerosis | - |
dc.subject.local | glycine max | - |
dc.subject.local | Glycine max | - |
dc.subject.local | Human acyl-coA: cholesterol acytransferase (hACAT) | - |
dc.subject.local | human acyl-CoA:cholesterol acyltransferase (hACAT) | - |
dc.subject.local | Root | - |
dc.subject.local | triterpenoid | - |
dc.subject.local | Triterpenoid | - |
dc.subject.local | Triterpenoids | - |
dc.subject.local | triterpenoids | - |
dc.description.journalClass | Y | - |
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