Biosynthesis of rubradirin as an ansamycin antibiotic from Streptomyces achromogenes var. rubradiris NRRL3061

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dc.contributor.authorC G Kim-
dc.contributor.authorJ Lamichhane-
dc.contributor.authorK I Song-
dc.contributor.authorV D Nguyen-
dc.contributor.authorD H Kim-
dc.contributor.authorT S Jeong-
dc.contributor.authorS H Kang-
dc.contributor.authorK W Kim-
dc.contributor.authorJ Maharjan-
dc.contributor.authorYoung-Soo Hong-
dc.contributor.authorJ S Kang-
dc.contributor.authorJ C Yoo-
dc.contributor.authorJung Joon Lee-
dc.contributor.authorT J Oh-
dc.contributor.authorK Liou-
dc.contributor.authorJ K Sohng-
dc.date.accessioned2017-04-19T09:10:10Z-
dc.date.available2017-04-19T09:10:10Z-
dc.date.issued2008-
dc.identifier.issn0003-9276-
dc.identifier.uri10.1007/s00203-007-0337-3ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8413-
dc.description.abstractThe four overlapping cosmids from the rubradirin producer, Streptomyces achromogenes var rubradiris NRRL 3061, have 58 ORFs within a 105.6 kb fragment. These ORFs harbored essential genes responsible for the formation and attachment of four distinct moieties, along with the genes associated with regulatory, resistance, and transport functions. The PKS (rubA) and glycosyltransferase (rubG2) genes were disrupted in order to demonstrate a complete elimination of rubradirin production. The rubradirin biosynthetic pathway was proposed based on the putative functions of the gene products, the functional identification of sugar genes, and the mutant strains.-
dc.publisherSpringer-
dc.titleBiosynthesis of rubradirin as an ansamycin antibiotic from Streptomyces achromogenes var. rubradiris NRRL3061-
dc.title.alternativeBiosynthesis of rubradirin as an ansamycin antibiotic from Streptomyces achromogenes var. rubradiris NRRL3061-
dc.typeArticle-
dc.citation.titleArchives of Microbiology-
dc.citation.number5-
dc.citation.endPage473-
dc.citation.startPage463-
dc.citation.volume189-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.affiliatedAuthorJung Joon Lee-
dc.contributor.alternativeName김천규-
dc.contributor.alternativeNameLamichhane-
dc.contributor.alternativeName송광일-
dc.contributor.alternativeNameNguyen-
dc.contributor.alternativeName김동희-
dc.contributor.alternativeName정태성-
dc.contributor.alternativeName강성호-
dc.contributor.alternativeName김경욱-
dc.contributor.alternativeNameMaharjan-
dc.contributor.alternativeName홍영수-
dc.contributor.alternativeName강재선-
dc.contributor.alternativeName유진철-
dc.contributor.alternativeName이정준-
dc.contributor.alternativeName오태진-
dc.contributor.alternativeName류광경-
dc.contributor.alternativeName송재경-
dc.identifier.bibliographicCitationArchives of Microbiology, vol. 189, no. 5, pp. 463-473-
dc.identifier.doi10.1007/s00203-007-0337-3-
dc.subject.keywordAnsamycin-
dc.subject.keywordBiosynthesis-
dc.subject.keywordPolyketide synthase-
dc.subject.keywordRubradirin-
dc.subject.keywordRubranitrose-
dc.subject.keywordStreptomyces-
dc.subject.localAnsamycin-
dc.subject.localbiosynthesis-
dc.subject.localBiosynthesis-
dc.subject.localPolyketide synthase-
dc.subject.localpolyketide synthase-
dc.subject.localrubradirin-
dc.subject.localRubradirin-
dc.subject.localrubranitrose-
dc.subject.localRubranitrose-
dc.subject.localstreptomyces-
dc.subject.localStreptomyces-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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