DC Field | Value | Language |
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dc.contributor.author | M C Song | - |
dc.contributor.author | H J Yang | - |
dc.contributor.author | Tae Sook Jeong | - |
dc.contributor.author | K T Kim | - |
dc.contributor.author | N I Baek | - |
dc.date.accessioned | 2017-04-19T09:10:16Z | - |
dc.date.available | 2017-04-19T09:10:16Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | 10.1007/s12272-001-1195-4 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8432 | - |
dc.description.abstract | The aerial parts of Chrysanthemum coronarium L. were extracted with MeOH, and the concentrated extract was partitioned using EtOAc, n-BuOH, and H 2O, successively. Repeated column chromatography of the EtOAc and n-BuOH fractions gave a new heterocycle, 5,5′-dibuthoxy-2,2′-bifuran (1) along with five known compounds: methyl trans-ferulate (2), prunasin (3), sambunigrin (4), pterolactam (5), and adenosine (6), which were identified by several spectroscopic methods including NMR and MS. This paper is the first report on the isolation of these compounds from C. coronarium L. The IC 50 values of compound 1 for human Acyl-CoA:cholesterol acyltransferase (hACAT)-1 and hACAT-2 were 0.16 mM and 0.19 mM, respectively. Compound 2 inhibited low-density lipoprotein (LDL) oxidation with an IC 50 value of 7.7 μM. | - |
dc.publisher | Pharmaceutical Soc Korea | - |
dc.title | Heterocyclic compounds from Chrysanthemum coronarium L. and their inhibitory activity on hACAT-1, hACAT-2, and LDL-oxidation | - |
dc.title.alternative | Heterocyclic compounds from Chrysanthemum coronarium L. and their inhibitory activity on hACAT-1, hACAT-2, and LDL-oxidation | - |
dc.type | Article | - |
dc.citation.title | Archives of Pharmacal Research | - |
dc.citation.number | 5 | - |
dc.citation.endPage | 578 | - |
dc.citation.startPage | 573 | - |
dc.citation.volume | 31 | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.alternativeName | 송 | - |
dc.contributor.alternativeName | 양 | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.contributor.alternativeName | 김 | - |
dc.contributor.alternativeName | 백남인 | - |
dc.identifier.bibliographicCitation | Archives of Pharmacal Research, vol. 31, no. 5, pp. 573-578 | - |
dc.identifier.doi | 10.1007/s12272-001-1195-4 | - |
dc.subject.keyword | 5,5′-Dibuthoxy-2,2′-bifuran | - |
dc.subject.keyword | Adenosine | - |
dc.subject.keyword | Chrysathemum coronarium L | - |
dc.subject.keyword | HACAT | - |
dc.subject.keyword | LDL-Oxidation | - |
dc.subject.keyword | Methyl trans-ferulate | - |
dc.subject.keyword | Prunasin | - |
dc.subject.keyword | Pterolactam | - |
dc.subject.keyword | Sambunigrin | - |
dc.subject.local | 5,5′-Dibuthoxy-2,2′-bifuran | - |
dc.subject.local | adenosine | - |
dc.subject.local | Adenosine | - |
dc.subject.local | Chrysathemum coronarium L | - |
dc.subject.local | hACAT | - |
dc.subject.local | HACAT | - |
dc.subject.local | LDL-oxidation | - |
dc.subject.local | LDL-Oxidation | - |
dc.subject.local | Methyl trans-ferulate | - |
dc.subject.local | Prunasin | - |
dc.subject.local | Pterolactam | - |
dc.subject.local | Sambunigrin | - |
dc.description.journalClass | Y | - |
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