DC Field | Value | Language |
---|---|---|
dc.contributor.author | W Yu | - |
dc.contributor.author | K Chung | - |
dc.contributor.author | M Cheon | - |
dc.contributor.author | M Heo | - |
dc.contributor.author | Kyou Hoon Han | - |
dc.contributor.author | S Ham | - |
dc.contributor.author | I Chang | - |
dc.date.accessioned | 2017-04-19T09:10:18Z | - |
dc.date.available | 2017-04-19T09:10:18Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | 10.1073/pnas.0708480105 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8444 | - |
dc.description.abstract | Recent experiments claiming that Naf-BBL protein follows a global downhill folding raised an important controversy as to the folding mechanism of fast-folding proteins. Under the global downhill folding scenario, not only do proteins undergo a gradual folding, but folding events along the continuous folding pathway also could be mapped out from the equilibrium denaturation experiment. Based on the exact calculation using a free energy landscape, relaxation eigenmodes from a master equation, and Monte Carlo simulation of an extended Mu?oz-Eaton model that incorporates multiscale-heterogeneous pairwise interactions between amino acids, here we show that the very nature of a two-state cooperative transition such as a bimodal distribution from an exact free energy landscape and biphasic relaxation kinetics manifest in the thermodynamics and folding-unfolding kinetics of BBL and peripheral subunit-binding domain homologues. Our results provide an unequivocal resolution to the fundamental controversy related to the global downhill folding scheme, whose applicability to other proteins should be critically reexamined. | - |
dc.publisher | Natl Acad Sciences | - |
dc.title | Cooperative folding kinetics of BBL protein and peripheral subunit-binding domain homologues | - |
dc.title.alternative | Cooperative folding kinetics of BBL protein and peripheral subunit-binding domain homologues | - |
dc.type | Article | - |
dc.citation.title | Proceedings of National Academy of Sciences of United States of America | - |
dc.citation.number | 7 | - |
dc.citation.endPage | 2402 | - |
dc.citation.startPage | 2397 | - |
dc.citation.volume | 105 | - |
dc.contributor.affiliatedAuthor | Kyou Hoon Han | - |
dc.contributor.alternativeName | 유우경 | - |
dc.contributor.alternativeName | 정광훈 | - |
dc.contributor.alternativeName | 천무경 | - |
dc.contributor.alternativeName | 허무영 | - |
dc.contributor.alternativeName | 한규훈 | - |
dc.contributor.alternativeName | 함시현 | - |
dc.contributor.alternativeName | 장익수 | - |
dc.identifier.bibliographicCitation | Proceedings of National Academy of Sciences of United States of America, vol. 105, no. 7, pp. 2397-2402 | - |
dc.identifier.doi | 10.1073/pnas.0708480105 | - |
dc.subject.keyword | Global downhill folding | - |
dc.subject.keyword | Protein folding mechanism | - |
dc.subject.keyword | Protein thermodynamics | - |
dc.subject.keyword | Relaxation kinetics of protein | - |
dc.subject.local | Global downhill folding | - |
dc.subject.local | Protein folding mechanism | - |
dc.subject.local | Protein thermodynamics | - |
dc.subject.local | Relaxation kinetics of protein | - |
dc.description.journalClass | Y | - |
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