Cooperative folding kinetics of BBL protein and peripheral subunit-binding domain homologues

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dc.contributor.authorW Yu-
dc.contributor.authorK Chung-
dc.contributor.authorM Cheon-
dc.contributor.authorM Heo-
dc.contributor.authorKyou Hoon Han-
dc.contributor.authorS Ham-
dc.contributor.authorI Chang-
dc.date.accessioned2017-04-19T09:10:18Z-
dc.date.available2017-04-19T09:10:18Z-
dc.date.issued2008-
dc.identifier.issn0027-8424-
dc.identifier.uri10.1073/pnas.0708480105ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8444-
dc.description.abstractRecent experiments claiming that Naf-BBL protein follows a global downhill folding raised an important controversy as to the folding mechanism of fast-folding proteins. Under the global downhill folding scenario, not only do proteins undergo a gradual folding, but folding events along the continuous folding pathway also could be mapped out from the equilibrium denaturation experiment. Based on the exact calculation using a free energy landscape, relaxation eigenmodes from a master equation, and Monte Carlo simulation of an extended Mu?oz-Eaton model that incorporates multiscale-heterogeneous pairwise interactions between amino acids, here we show that the very nature of a two-state cooperative transition such as a bimodal distribution from an exact free energy landscape and biphasic relaxation kinetics manifest in the thermodynamics and folding-unfolding kinetics of BBL and peripheral subunit-binding domain homologues. Our results provide an unequivocal resolution to the fundamental controversy related to the global downhill folding scheme, whose applicability to other proteins should be critically reexamined.-
dc.publisherNatl Acad Sciences-
dc.titleCooperative folding kinetics of BBL protein and peripheral subunit-binding domain homologues-
dc.title.alternativeCooperative folding kinetics of BBL protein and peripheral subunit-binding domain homologues-
dc.typeArticle-
dc.citation.titleProceedings of National Academy of Sciences of United States of America-
dc.citation.number7-
dc.citation.endPage2402-
dc.citation.startPage2397-
dc.citation.volume105-
dc.contributor.affiliatedAuthorKyou Hoon Han-
dc.contributor.alternativeName유우경-
dc.contributor.alternativeName정광훈-
dc.contributor.alternativeName천무경-
dc.contributor.alternativeName허무영-
dc.contributor.alternativeName한규훈-
dc.contributor.alternativeName함시현-
dc.contributor.alternativeName장익수-
dc.identifier.bibliographicCitationProceedings of National Academy of Sciences of United States of America, vol. 105, no. 7, pp. 2397-2402-
dc.identifier.doi10.1073/pnas.0708480105-
dc.subject.keywordGlobal downhill folding-
dc.subject.keywordProtein folding mechanism-
dc.subject.keywordProtein thermodynamics-
dc.subject.keywordRelaxation kinetics of protein-
dc.subject.localGlobal downhill folding-
dc.subject.localProtein folding mechanism-
dc.subject.localProtein thermodynamics-
dc.subject.localRelaxation kinetics of protein-
dc.description.journalClassY-
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