Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor = Benzothiazole amide 및 urea 유도체의 합성과 Raf-1에 대한 활성평가

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Title
Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor = Benzothiazole amide 및 urea 유도체의 합성과 Raf-1에 대한 활성평가
Author(s)
Eun Young Song; N Kaur; M Y Park; Y Jin; Kyeong Lee; G Kim; K Y Lee; J S Yang; J H Shin; K Y Nam; K T No; G Han
Bibliographic Citation
European Journal of Medicinal Chemistry, vol. 43, no. 7, pp. 1519-1524
Publication Year
2008
Abstract
A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.
Keyword
antiproliferativebenzothiazole derivativesRaf-1 activity
ISSN
0223-5234
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.ejmech.2007.10.008
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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