DAhunter: a web-based server that identifies homologous proteins by comparing domain architecture

Cited 12 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorByungUk Lee-
dc.contributor.authorD Lee-
dc.date.accessioned2017-04-19T09:10:48Z-
dc.date.available2017-04-19T09:10:48Z-
dc.date.issued2008-
dc.identifier.issn0305-1048-
dc.identifier.uri10.1093/nar/gkn172ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8470-
dc.description.abstractWe present DAhunter, a web-based server that identifies homologous proteins by comparing domain architectures, the organization of protein domains. A major obstacle in comparison of domain architecture is the existence of 'promiscuous' domains, which carry out auxiliary functions and appear in many unrelated proteins. To distinguish these promiscuous domains from protein domains, we assigned a weight score to each domain extracted from RefSeq proteins, based on its abundance and versatility. A domain's score represents its importance in the 'protein world' and is used in the comparison of domain architectures. In scoring domains, DAhunter also considers domain combinations as well as single domains. To measure the similarity of two domain architectures, we developed several methods that are based on algorithms used in information retrieval (the cosine similarity, the Goodman-Kruskal gamma function, and domain duplication index) and then combined these into a similarity score. Compared with other domain architecture algorithms, DAhunter is better at identifying homology.-
dc.publisherOxford Univ Press-
dc.titleDAhunter: a web-based server that identifies homologous proteins by comparing domain architecture-
dc.title.alternativeDAhunter: a web-based server that identifies homologous proteins by comparing domain architecture-
dc.typeArticle-
dc.citation.titleNucleic Acids Research-
dc.citation.numberSup 2-
dc.citation.endPageW64-
dc.citation.startPageW60-
dc.citation.volume36-
dc.contributor.affiliatedAuthorByungUk Lee-
dc.contributor.alternativeName이병욱-
dc.contributor.alternativeName이도헌-
dc.identifier.bibliographicCitationNucleic Acids Research, vol. 36, no. Sup 2, pp. W60-W64-
dc.identifier.doi10.1093/nar/gkn172-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.