Open Access@KRIBBDivision of Research on National ChallengesBionanotechnology Research Center1. Journal Articles
Discovery of VHR phosphatase inhibitors with micromolar activity based on structure-based virtual screening = 구조기반 가상설계를 이용한 VHR 저해제 연구
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- Title
- Discovery of VHR phosphatase inhibitors with micromolar activity based on structure-based virtual screening = 구조기반 가상설계를 이용한 VHR 저해제 연구
- Author(s)
- H Park; Suk Kyeong Jung; Dae Gwin Jeong; Seong Eon Ryu; Seung Jun Kim
- Bibliographic Citation
- Chemmedchem, vol. 3, no. 6, pp. 877-880
- Publication Year
- 2008
- Abstract
- (Chemical Equation Presented) Human VHR phosphatase has been shown to be involved in the regulation of cell-cycle progression and is itself modulated during the cell cycle, indicating that VHR can serve as a therapeutic target for cancer. In the present study, we identify new VHR inhibitors by means of a structure-based drug design protocol involving the virtual screening with docking simulations and in vitro enzyme assay.
- ISSN
- 1860-7187
- Publisher
- Wiley
- Full Text Link
- http://dx.doi.org/10.1002/cmdc.200700348
- Type
- Article
- Appears in Collections:
- Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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