Glyco-engineering of biotherapeutic proteins in plants

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Title
Glyco-engineering of biotherapeutic proteins in plants
Author(s)
K Ko; M H Ahn; M Song; Y K Choo; Hyun Soon Kim; K Ko; Hyouk Joung
Bibliographic Citation
Molecules and Cells, vol. 25, no. 4, pp. 494-503
Publication Year
2008
Abstract
Many therapeutic glycoproteins have been successfully generated in plants. Plants have advantages regarding practical and economic concerns, and safety of protein production over other existing systems. However, plants are not ideal expression systems for the production of biopharmaceutical proteins, due to the fact that they are incapable of the authentic human N-glycosylation process. The majority of therapeutic proteins are glycoproteins which harbor N-glycans, which are often essential for their stability, folding, and biological activity. Thus, several glyco-engineering strategies have emerged for the tailor-making of N-glycosylation in plants, including glycoprotein subcellular targeting, the inhibition of plant specific glycosyltranferases, or the addition of human specific glycosyltransferases. This article focuses on plant N-glycosylation structure, glycosylation variation in plant cell, plant expression system of glycoproteins, and impact of glycosylation on immunological function. Furthermore, plant glyco-engineering techniques currently being developed to overcome the limitations of plant expression systems in the production of therapeutic glycoproteins will be discussed in this review.
Keyword
glycoproteinglycosylationmolecular biopharmingmonoclonal antibodyrecombinant proteintransgenic plant
ISSN
1016-8478
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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