Anticomplementary activity of triterpenoids from the whole plant of Aceriphyllum rossii against the classical pathway

Cited 23 time in scopus
Metadata Downloads
Title
Anticomplementary activity of triterpenoids from the whole plant of Aceriphyllum rossii against the classical pathway
Author(s)
B S Min; I Lee; M J Chang; J K Yoo; M Na; T M Hung; P T Thuong; J Lee; Jung Hee Kim; J C Kim; M H Woo; J S Choi; Hyeong Kyu Lee; K Bae
Bibliographic Citation
Planta Medica, vol. 74, no. 7, pp. 726-729
Publication Year
2008
Abstract
To provide a better understanding of the anti-complement activity of triterpenoids, seven unusual pentacyclic triterpenoids bearing a carboxyl group at C-27 were evaluated for their anti-complement activities against the classical pathway of the complement system. The triterpenoids were isolated from the whole plant of Aceriphyllum rossii of the family Saxifragaceae and were determined to be 3α,23-isopropylidenedioxyolean-12-en-27-oic acid (1), 3-oxoolean-12-en-27-oic acid (2), 3α-hydroxyolean-12-en-27-oic acid (3), β-peltoboykinolic acid (4), 3α,23-diacetoxyolean-12-en-27-oic acid (5), 23-hydroxy-3-oxoolean-12-en-27-oic acid (6) and aceriphyllic acid A (7). Among them, compounds 2, 3, and 5 showed significant anticomplement activity on the classical pathway with IC50 values of 71.4, 98.5, and 180.7 μM, respectively, whereas compounds 1, 4, 6, and 7 were inactive. Our findings suggest that both the ketone at C-3 and the methyl at C-23 in the oleanane triterpenoids with a carboxyl group at C-27 are important for the anticomplement activity against the classical pathway.
Keyword
Aceriphyllum rossiiAnticomplement activityClassical pathwaySaxifragaceaeOlean-27-carboxylic acid derivatives
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2008-1074534
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.