Identification of small molecules inducing apoptosis by cell-based assay using fission yeast deletion mutants

Cited 10 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorKyung Sook Chung-
dc.contributor.authorNam-Hui Yim-
dc.contributor.authorS H Lee-
dc.contributor.authorShin Jung Choi-
dc.contributor.authorK S Heo-
dc.contributor.authorKwang Lae Hoe-
dc.contributor.authorDong Uk Kim-
dc.contributor.authorS Goehle-
dc.contributor.authorH B Kim-
dc.contributor.authorK B Song-
dc.contributor.authorHyang Sook Yoo-
dc.contributor.authorK H Bae-
dc.contributor.authorJ Simon-
dc.contributor.authorMi Sun Won-
dc.date.accessioned2017-04-19T09:11:09Z-
dc.date.available2017-04-19T09:11:09Z-
dc.date.issued2008-
dc.identifier.issn0167-6997-
dc.identifier.uri10.1007/s10637-007-9100-5ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8497-
dc.description.abstractThe cell-based assay using yeast deletion mutants has been recognized as an efficient analysis to discover therapeutic compounds and reveal their mode of action. In this study, S. pombe deletion mutants-based HTS screening was carried out to identify potential anti-cancer agents. The NCI chemical library of 5700 compounds was screened using kit strains, which consisted of S. pombe mutants harboring deletions in genes involved in DNA repair and mitotic control. During the screening, we identified 40 compounds conferring growth inhibition of S. pombe. Their anti-tumorigenic properties were examined by phenotypic effect on S. pombe, flow cytometry and apoptosis analysis of human cancer. Here, we report hit compounds inducing apoptosis for development of anti-cancer agents suggesting that S. pombe deletion mutants are useful in identifying potential anti-cancer agents in human cancer therapeutics.-
dc.publisherSpringer-
dc.titleIdentification of small molecules inducing apoptosis by cell-based assay using fission yeast deletion mutants-
dc.title.alternativeIdentification of small molecules inducing apoptosis by cell-based assay using fission yeast deletion mutants-
dc.typeArticle-
dc.citation.titleInvestigational New Drugs-
dc.citation.number4-
dc.citation.endPage307-
dc.citation.startPage299-
dc.citation.volume26-
dc.contributor.affiliatedAuthorKyung Sook Chung-
dc.contributor.affiliatedAuthorNam-Hui Yim-
dc.contributor.affiliatedAuthorShin Jung Choi-
dc.contributor.affiliatedAuthorKwang Lae Hoe-
dc.contributor.affiliatedAuthorDong Uk Kim-
dc.contributor.affiliatedAuthorHyang Sook Yoo-
dc.contributor.affiliatedAuthorMi Sun Won-
dc.contributor.alternativeName정경숙-
dc.contributor.alternativeName임남희-
dc.contributor.alternativeName이승희-
dc.contributor.alternativeName최신정-
dc.contributor.alternativeName허경선-
dc.contributor.alternativeName허광래-
dc.contributor.alternativeName김동욱-
dc.contributor.alternativeNameGoehle-
dc.contributor.alternativeName김형배-
dc.contributor.alternativeName송경빈-
dc.contributor.alternativeName유향숙-
dc.contributor.alternativeName배기환-
dc.contributor.alternativeNameSimon-
dc.contributor.alternativeName원미선-
dc.identifier.bibliographicCitationInvestigational New Drugs, vol. 26, no. 4, pp. 299-307-
dc.identifier.doi10.1007/s10637-007-9100-5-
dc.subject.keywordAnti-cancer compound-
dc.subject.keywordApoptosis-
dc.subject.keywordFission yeast-
dc.subject.localAnti-cancer compound-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localFission yeast-
dc.subject.localfission yeast-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > 1. Journal Articles
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.