Inhibitory effect of dalbergioidin isolated from the trunk of Lespedeza cyrtobotrya on melanin biosynthesis

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dc.contributor.authorSeung Hwa Baek-
dc.contributor.authorJ Kim-
dc.contributor.authorD Kim-
dc.contributor.authorC Lee-
dc.contributor.authorJ Kim-
dc.contributor.authorDae Gwin Jeong-
dc.contributor.authorC Lee-
dc.date.accessioned2017-04-19T09:11:11Z-
dc.date.available2017-04-19T09:11:11Z-
dc.date.issued2008-
dc.identifier.issn10177825-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8507-
dc.description.abstractTyrosinase is a key enzyme for melanin biosynthesis, and hyperpigmentation disorders are associated with abnormal accumulation of melanin pigments, which can be reduced by treatment with depigmenting agents. The methanol extract of Lespedeza cyrtobotrya MIQ showed inhibitory activity against mushroom tyrosinase. The active compound was purified from the methanol extract of L. cyrtobotrya, followed by several chromatographic methods, and identified as dalbergioidin (DBG) by spectroscopic methods. The results showed that DBG exhibited tyrosinase inhibitory activity with an IC50 of 20 μM. The kinetic analysis of tyrosinase inhibition revealed that DBG acted as a noncompetitive inhibitor. In addition, DBG showed a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Furthermore, 27 μM DBG decreased more than 50% of melanin contents on the pigmentation using the immortalized mouse melanocyte, melan-a cell.-
dc.publisherSouth Korea-
dc.titleInhibitory effect of dalbergioidin isolated from the trunk of Lespedeza cyrtobotrya on melanin biosynthesis-
dc.title.alternativeInhibitory effect of dalbergioidin isolated from the trunk of Lespedeza cyrtobotrya on melanin biosynthesis-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number5-
dc.citation.endPage879-
dc.citation.startPage874-
dc.citation.volume18-
dc.contributor.affiliatedAuthorDae Gwin Jeong-
dc.contributor.alternativeName백승화-
dc.contributor.alternativeName김진희-
dc.contributor.alternativeName김동현-
dc.contributor.alternativeName이찬용-
dc.contributor.alternativeName김지영-
dc.contributor.alternativeName정대균-
dc.contributor.alternativeName이충환-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 18, no. 5, pp. 874-879-
dc.subject.keyworddalbergioidin-
dc.subject.keywordlespedeza cyrtobotrya-
dc.subject.keywordmelan-a cell-
dc.subject.keywordmelanin biosynthesis inhibitor-
dc.subject.keywordskin-whitening-
dc.subject.keywordtyrosinase-
dc.subject.localdalbergioidin-
dc.subject.locallespedeza cyrtobotrya-
dc.subject.localmelan-a cell-
dc.subject.localmelanin biosynthesis inhibitor-
dc.subject.localskin-whitening-
dc.subject.localskin whitening-
dc.subject.localtyrosinase-
dc.subject.localTyrosinase-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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