Bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of VCAM-1 expression

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Title
Bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of VCAM-1 expression
Author(s)
D I Sun; I T Nizamutdinova; Y M Kim; X F Cai; Jung Joon Lee; S S Kang; Y S Kim; K M Kang; G Y Chai; K C Chang; H J Kim
Bibliographic Citation
International Immunopharmacology, vol. 8, no. 9, pp. 1272-1281
Publication Year
2008
Abstract
Bisacurone, one of the active compounds of the traditionally used indigenous herb Curcuma longa Linne (Zingiberaceae), has anti-oxidant, anti-inflammatory, and anti-metastatic activities. We studied how the level of vascular cell adhesion molecule-1 (VCAM-1), one of the key molecules in the development of atherosclerosis as well as carcinogenesis and metastasis, might be affected by bisacurone in tumor necrosis factor-alpha (TNF-α)-activated human umbilical vein endothelial cells (HUVECs). Bisacurone dose-dependently inhibited TNF-α-mediated expression of VCAM-1. It showed significant suppressive effect on ROS generation in response to TNF-α stimulation and it blocked nuclear factor-kappa B (NF-κB) p65 translocation into the nucleus and phosphorylation of inhibitory factor κBα (IκBα). It also inhibited phosphorylation of Akt and PKC, which are upstream in the regulation of VCAM-1 by TNF-α. Furthermore, bisacurone decreased U937 monocyte and human oral cancer cell (Hep-2, QLL-I, SCC-15) adhesion to HUVECs stimulated by TNF-α, suggesting that it may inhibit the binding of these cells by regulating the expression of critical adhesion molecules by TNF-α. Thus, bisacurone may be beneficial in the treatment of inflammatory diseases, such as atherosclerosis, where inflammatory monocytes are involved in their pathology, and, moreover, in the development of tumors.
Keyword
BisacuroneInflammatory diseaseMetastasisNF-kappa BReactive oxygen speciesVascular cell adhesion molecule-1
ISSN
1567-5769
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.intimp.2008.05.006
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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