Protein tyrosine phosphatase 1B inhibitory activity of anthraguinones and stilbenes

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Title
Protein tyrosine phosphatase 1B inhibitory activity of anthraguinones and stilbenes
Author(s)
M Na; W Y Jin; B S Min; Jong Seog Ahn; K Bae
Bibliographic Citation
Natural Products Sciences, vol. 14, no. 2, pp. 143-146
Publication Year
2008
Abstract
Protein tyrosine phosphatase IB (PTP1B) is emerging as a potential therapeutic target for the treatment of type-2 diabetes and obesity. To search for new types of FTP1B inhibitors, we have undertaken in vitro enzyme assay for some anthraquinones and stilbenes isolated from plants. of the anthraquinones tested, physcion (1), 1-O-methylemodin (2), and emodin (3) showed high activities, with IC50 values of 7.6, 7.0, and 3.8 μg/mL, respectively, while the anthraquinone glycosides, physcion-8-O-β-D- glucopyranoside (4) and emodin-8-O-(3-D-glucopyranoside (5), were less active than their aglycones. All the stilbenens (6 -15) slightly inhibited PTP1B activity at high concentration of 30 μg/mL. Our findings suggest that the hypoglycemic effect of anthraquinones may be associated with their PTP1B inhibitory activity.
Keyword
anthraquinonesin vitro enzyme assayprotein tyrosine phosphatase 1B (FTPIB)stilbenes
ISSN
I000-0147
Publisher
Korean Society of Pharmacognosy
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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