Inhibition of atopic dermatitis by topical application of silymarin in NC/Nga mice

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Title
Inhibition of atopic dermatitis by topical application of silymarin in NC/Nga mice
Author(s)
Jong Soon KangWoon Kee Yoon; M H Han; H Lee; Chang Woo LeeKi Hoon Lee; S B Han; Kiho Lee; K H Yang; Song Kyu Park; Hwan Mook Kim
Bibliographic Citation
International Immunopharmacology, vol. 8, no. 10, pp. 1475-1480
Publication Year
2008
Abstract
Silymarin has been known to inhibit chemical-induced irritant contact dermatitis. In the present study, we report that topical application of silymarin suppresses dust mite extract (DPE)-induced atopic dermatitis (AD) in NC/Nga mice. Repeated topical application of ears with DPE caused AD-like skin lesions in NC/Nga mice. However, silymarin reduced AD-like skin lesions in these mice, resulting in decreased ear swelling and leukocyte infiltration into the ear. Moreover, our results showed that mast cell infiltration into the ear was suppressed by silymarin treatment in DPE-treated NC/Nga mice. Silymarin also reduced plasma level of IL-4 and IgE in these mice. Further study demonstrated that the mRNA expression of IL-4 was increased and that of IFN-γ was decreased by DPE treatment in the ears of NC/Nga mice. However, DPE-induced changes in IL-4 and IFN-γ mRNA expression were reversed by silymarin. DPE-induced increase in TNF-α mRNA expression was also suppressed by silymarin treatment. The results presented in this report suggest that silymarin might be beneficial for the treatment of AD.
Keyword
Atopic dermatitisIL-4NC/NgaSilymarinTNF-α
ISSN
1567-5769
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.intimp.2008.06.004
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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