A cytotoxic and apoptosis-inducing sesquiterpenoid isolated from the aerial parts of Artemisia princeps PAMPANINI (Sajabalssuk)

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dc.contributor.authorM H Bang-
dc.contributor.authorM W Han-
dc.contributor.authorM C Song-
dc.contributor.authorJ G Cho-
dc.contributor.authorH G Chung-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorK T Lee-
dc.contributor.authorM S Choi-
dc.contributor.authorS Y Kim-
dc.contributor.authorN I Baek-
dc.date.accessioned2017-04-19T09:11:26Z-
dc.date.available2017-04-19T09:11:26Z-
dc.date.issued2008-
dc.identifier.issn0009-2363-
dc.identifier.uri10.1248/cpb.56.1168ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8553-
dc.description.abstractRepeated silica gel and octadecyl silica gel (ODS) column chromatography of the aerial parts of Artemisia princeps PAMPANINI (Sajabalssuk) led to the isolation of a new sesquiterpenoid, 3-((S)-2-methylbutyryloxy)-costu-1(10),4(5)- dien-12,6α-olide (2), along with two previously reported sesquiterpenoids: 8α-angeloyloxy-3β,4β-epoxy-6βH,7αH,8βH-guaia- 1(10),11(13)-dien-12,6α-olide (1, carlaolide B) and 3β,4β-epoxy- 8α-isobutyryloxy-6βH,7αH,8βH-guaia-1(10),11(13)-dien-12, 6α-olide (3, carlaolide A). The structure of compound 2 was elucidated by spectroscopic data analysis, including one dimensional (1D) and two dimensional (2D) nuclear magnetic resonance (NMR) experiments. of the isolates, compound 2 exhibited potent cytotoxicity against human cervix adenocarcinoma cells and induced apoptosis.-
dc.publisherPharmaceutical Soc Japan-
dc.titleA cytotoxic and apoptosis-inducing sesquiterpenoid isolated from the aerial parts of Artemisia princeps PAMPANINI (Sajabalssuk)-
dc.title.alternativeA cytotoxic and apoptosis-inducing sesquiterpenoid isolated from the aerial parts of Artemisia princeps PAMPANINI (Sajabalssuk)-
dc.typeArticle-
dc.citation.titleChemical & Pharmaceutical Bulletin-
dc.citation.number8-
dc.citation.endPage1172-
dc.citation.startPage1168-
dc.citation.volume56-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName방면호-
dc.contributor.alternativeName한민우-
dc.contributor.alternativeName송명종-
dc.contributor.alternativeName조진경-
dc.contributor.alternativeName정해곤-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName이경태-
dc.contributor.alternativeName최명숙-
dc.contributor.alternativeName김세영-
dc.contributor.alternativeName백남인-
dc.identifier.bibliographicCitationChemical & Pharmaceutical Bulletin, vol. 56, no. 8, pp. 1168-1172-
dc.identifier.doi10.1248/cpb.56.1168-
dc.subject.keyword3-((S)-2-methylbutyryloxy)- costu-1(10),4(5)-dien-12,6α-olide-
dc.subject.keywordApoptosis-
dc.subject.keywordArtemisia princeps-
dc.subject.keywordCarlaolide A-
dc.subject.keywordCarlaolide B-
dc.subject.keywordCytotoxicity-
dc.subject.local3-((S)-2-methylbutyryloxy)-costu-1(10),4(5)-dien-12,6a -olide-
dc.subject.local3-((S)-2-methylbutyryloxy)- costu-1(10),4(5)-dien-12,6α-olide-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localArtemisia princeps-
dc.subject.localartemisia princeps-
dc.subject.localcarlaolide A-
dc.subject.localCarlaolide A-
dc.subject.localcarlaolide B-
dc.subject.localCarlaolide B-
dc.subject.localCytotoxicity-
dc.subject.localcytotoxicity-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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