Minisatellite polymorphisms of the SLC6A19: Susceptibility in hypertension = 유전자 SLC6A19의 Minisatellite 다형성 : Susceptibility in hypertension

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Title
Minisatellite polymorphisms of the SLC6A19: Susceptibility in hypertension = 유전자 SLC6A19의 Minisatellite 다형성 : Susceptibility in hypertension
Author(s)
S Y Seol; Sang-Yeop Lee; Y D Kim; E J Do; J A Kwon; S I Kim; In-Sun Chu; S H Leem
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 374, no. 4, pp. 714-719
Publication Year
2008
Abstract
The SLC6A19 is a human homolog of B0AT1 that encodes a neutral amino acid transporter. We examined the distribution of VNTR (variable number of tandem repeats; minisatellites) and conducted polymorphic analysis of SCL6A19 isolated from the genomic DNA of controls and multi-generational families. The SLC6A19 was found to contain seven blocks of minisatellites, 3 of which (SLC6A19-MS1, -MS4, and -MS7) showed polymorphism and were found to be transmitted through meiosis following Mendelian inheritance in seven families. These minisatellite polymorphisms may be useful markers for paternity mapping and DNA fingerprinting. Furthermore, we conducted a case-control study in which genomic DNA from 400 controls and 205 cases with essential hypertension was compared. A statistically significant association was identified between rare SLC6A19-MS7 alleles and the occurrence of hypertension (odds ratio, 7.87; 95% confidence interval, 0.88-70.66; and p = 0.028). These findings suggest that the rare SLC6A19-MS7 allele may be a risk factor for hypertension.
Keyword
Essential hypertensionMinisatellite polymorphismsNeurotransmitter transporterSLC6A19VNTR
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2008.07.094
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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