Comparative proteomic analysis of peripheral blood mononuclear cells from atopic dermatitis patients and healthy donors = 아토피환자와 정상인의 혈액의 비교단백질체학분석

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dc.contributor.authorWon Kon-Kim-
dc.contributor.authorHyun Ju Cho-
dc.contributor.authorS I Ryu-
dc.contributor.authorH R Hwang-
dc.contributor.authorD H Kim-
dc.contributor.authorH Y Ryu-
dc.contributor.authorJin Woong Chung-
dc.contributor.authorT Y Kim-
dc.contributor.authorByoung Chul Park-
dc.contributor.authorKwang-Hee Bae-
dc.contributor.authorY Ko-
dc.contributor.authorSang Chul Lee-
dc.date.accessioned2017-04-19T09:11:32Z-
dc.date.available2017-04-19T09:11:32Z-
dc.date.issued2008-
dc.identifier.issn1225-8687-
dc.identifier.uri10.5483/BMBRep.2008.41.8.597ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8563-
dc.description.abstractAtopic dermatitis (AD) is a chronic inflammatory skin disease that induces changes in various inflammatory skin cells. The prevalence of AD is as high as 18% in some regions of the world, and is steadily rising. However, the pathophysiology of AD is poorly understood. To identify the proteins involved in AD pathogenesis, a comparative proteomic analysis of protein expression in peripheral blood mononuclear cells isolated from AD patients and healthy donors was conducted. Significant changes were observed in the expressions of fourteen proteins, including the vinculin, PITPNB, and Filamin A proteins. Among the proteins, α-SNAP and FLNA decreased significantly, and PITPNB increased significantly in AD patients compared with control subjects; these findings were further confirmed by real-time PCR and Western blot analysis. The comparative proteome data may provide a valuable clue to further understand AD pathogenesis, and several differentially regulated proteins may be used as biomarkers for diagnosis and as target proteins for the development of novel drugs.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleComparative proteomic analysis of peripheral blood mononuclear cells from atopic dermatitis patients and healthy donors = 아토피환자와 정상인의 혈액의 비교단백질체학분석-
dc.title.alternativeComparative proteomic analysis of peripheral blood mononuclear cells from atopic dermatitis patients and healthy donors-
dc.typeArticle-
dc.citation.titleBMB Reports-
dc.citation.number8-
dc.citation.endPage603-
dc.citation.startPage597-
dc.citation.volume41-
dc.contributor.affiliatedAuthorWon Kon-Kim-
dc.contributor.affiliatedAuthorHyun Ju Cho-
dc.contributor.affiliatedAuthorJin Woong Chung-
dc.contributor.affiliatedAuthorByoung Chul Park-
dc.contributor.affiliatedAuthorKwang-Hee Bae-
dc.contributor.affiliatedAuthorSang Chul Lee-
dc.contributor.alternativeName김원곤-
dc.contributor.alternativeName조현주-
dc.contributor.alternativeName류수인-
dc.contributor.alternativeName황향란-
dc.contributor.alternativeName김도형-
dc.contributor.alternativeName류혜영-
dc.contributor.alternativeName정진웅-
dc.contributor.alternativeName김태윤-
dc.contributor.alternativeName박병철-
dc.contributor.alternativeName배광희-
dc.contributor.alternativeName고용-
dc.contributor.alternativeName이상철-
dc.identifier.bibliographicCitationBMB Reports, vol. 41, no. 8, pp. 597-603-
dc.identifier.doi10.5483/BMBRep.2008.41.8.597-
dc.subject.keywordAtopic dermatitis-
dc.subject.keywordBiomarker-
dc.subject.keywordPeripheral blood mononuclear cells-
dc.subject.keywordProteomics-
dc.subject.localAtopic Dermatitis-
dc.subject.localAtopic dermatitis-
dc.subject.localatopic dermatitis (AD)-
dc.subject.localatopic dermatitis-
dc.subject.localBiomarker-
dc.subject.localBiomarkers-
dc.subject.localbio-marker-
dc.subject.localbiomarker-
dc.subject.localPeripheral blood mononuclear cell (PBMC)-
dc.subject.localPeripheral blood mononuclear cell-
dc.subject.localPeripheral blood mononuclear cells-
dc.subject.localProteomic-
dc.subject.localProteomics-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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