Identification of proteins binding to decursinol by chemical proteomics = 화학단백질체학을 이용한 디커시놀 결합 단백질의 발굴

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Title
Identification of proteins binding to decursinol by chemical proteomics = 화학단백질체학을 이용한 디커시놀 결합 단백질의 발굴
Author(s)
Hyo Jin Kang; Tae-Sung YoonDae Gwin Jeong; Yongmo Kim; Jin Woong Chung; Jong Seong Ha; Sung Sup Park; Seong Eon Ryu; S Kim; Kwang-Hee Bae; Sang Jeon Chung
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 18, no. 8, pp. 1427-1430
Publication Year
2008
Abstract
Decursinol, found in the roots of Angelica gigas Nakai, has been traditionally used to treat anemia and other various diseases. Recently, numerous biological activities such as cytotoxic effect on leukemia cells, and antitumor, neuroprotection, and antibacterial activities have been reported for this compound. Although a number of proteins including protein kinase C, androgen receptor, and acetylcholinesterase were proposed as molecular targets responsible for the activities of decursinol, they are not enough to explain such a diverse biological activity mentioned above. In this study, we employed a chemical proteomic approach, leading to identification of seven proteins as potential proteins interacting with decursinol. Most of the proteins contain a defined ATP or nucleic acid binding domain and have been implied to be involved in the pathogenesis and progression of various human diseases including cancer, autoimmune disorders, or neurodegenerative diseases. The present results may provide clues to understand the molecular mechanism of the biological activities shown by decursinol, an anticancer natural product.
Keyword
anticancerchemical proteomicsdecursinolenolaseHsp90
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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