Transgenic tomatoes expressing human beta-amyloid for use as a vaccine against Alzheimer's disease

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dc.contributor.authorJung Won Youm-
dc.contributor.authorJae Heung Jeon-
dc.contributor.authorH Kim-
dc.contributor.authorY H Kim-
dc.contributor.authorK Ko-
dc.contributor.authorHyouk Joung-
dc.contributor.authorHyun Soon Kim-
dc.date.accessioned2017-04-19T09:11:38Z-
dc.date.available2017-04-19T09:11:38Z-
dc.date.issued2008-
dc.identifier.issn01415492-
dc.identifier.uri10.1007/s10529-008-9759-5ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8577-
dc.description.abstractHuman β-amyloid (Aβ) is believed to be one of the main components of Alzheimer's disease, so reduction of Aβ is considered a key therapeutic target. Using Agrobacterium-mediated nuclear transformation, we generated transgenic tomatoes for Aβ with tandem repeats. Integration of the human Aβ gene into the tomato genome and its transcription were detected by PCR and Northern blot, respectively. Expression of the Aβ protein was confirmed by western blot and ELISA, and then the transgenic tomato line expressing the highest protein level was selected for vaccination. Mice immunized orally with total soluble extracts from the transgenic tomato plants elicited an immune response after receiving a booster. The results indicate that tomato plants may provide a useful system for the production of human Aβ antigen.-
dc.publisherSpringer-
dc.titleTransgenic tomatoes expressing human beta-amyloid for use as a vaccine against Alzheimer's disease-
dc.title.alternativeTransgenic tomatoes expressing human beta-amyloid for use as a vaccine against Alzheimer's disease-
dc.typeArticle-
dc.citation.titleBiotechnology Letters-
dc.citation.number10-
dc.citation.endPage1845-
dc.citation.startPage1839-
dc.citation.volume30-
dc.contributor.affiliatedAuthorJae Heung Jeon-
dc.contributor.affiliatedAuthorHyun Soon Kim-
dc.contributor.alternativeName염정원-
dc.contributor.alternativeName전재흥-
dc.contributor.alternativeName김희-
dc.contributor.alternativeName김영호-
dc.contributor.alternativeName고기성-
dc.contributor.alternativeName정혁-
dc.contributor.alternativeName김현순-
dc.identifier.bibliographicCitationBiotechnology Letters, vol. 30, no. 10, pp. 1839-1845-
dc.identifier.doi10.1007/s10529-008-9759-5-
dc.subject.keywordAlzheimer's disease-
dc.subject.keywordedible vaccine-
dc.subject.keywordimmunogenicity-
dc.subject.keywordtomato-derived beta amyloid-
dc.subject.localAlzheimer's disease-
dc.subject.localAlzheimer’s disease-
dc.subject.localedible vaccine-
dc.subject.localEdible vaccine-
dc.subject.localimmunogenicity-
dc.subject.localImmunogenicity-
dc.subject.localtomato-derived beta amyloid-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Plant Systems Engineering Research > 1. Journal Articles
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