Microarray study of genes differentially modulated in response to nitric oxide in macrophages

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dc.contributor.authorX Nan-
dc.contributor.authorO Maeng-
dc.contributor.authorH Shin-
dc.contributor.authorH J An-
dc.contributor.authorYoung Il Yeom-
dc.contributor.authorH Lee-
dc.contributor.authorS G Paik-
dc.date.accessioned2017-04-19T09:11:41Z-
dc.date.available2017-04-19T09:11:41Z-
dc.date.issued2008-
dc.identifier.issn19768354-
dc.identifier.uri10.1080/19768354.2008.9647149ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8586-
dc.description.abstractNitric oxide (NO) has been known to play important roles in numerous physiologic processes including neurotransmission, vasorelaxation, and cellular apoptosis. Using a mouse cDNA gene chip, we examined expression patterns and time course of NO-dependent genes in mouse macrophage RAW264.7 cells. Genes shown to be upregulated more than two fold or at least at two serial time points were further selected and validated by RT-PCR. Finally, 81 selected genes were classified by function as signaling, apoptosis, inflammation, transcription, translation, ionic homeostasis and metabolism. Among those, genes related with signaling, apoptosis and inflammation, such as guanylate cyclase 1, soluble, alpha3 (Gucy1a3); protein kinase C, alpha (Pkcα); lymphocyte protein tyrosine kinase (Lck); BCL2/adenovirus E1B 19 kDa-interacting protein (Bnip3); apoptotic protease activating factor 1 (Apaf1); Xlinked inhibitor of apoptosis (Xiap); cyclin G1 (Ccng1); chemokine (C-C motif) ligand 4 (Ccl4); B cell translocation gene 2, anti-proliferative (Btg2); lysozyme 2 (Lyz2); secreted phosphoprotein 1 (Spp1); heme oxygenase (decycling) 1 (Hmox1); CD14 antigen (Cd14); and granulin (Grn) may play important roles in NO-dependent responses in murine macrophages.-
dc.publisherT&F (Taylor & Francis)-
dc.titleMicroarray study of genes differentially modulated in response to nitric oxide in macrophages-
dc.title.alternativeMicroarray study of genes differentially modulated in response to nitric oxide in macrophages-
dc.typeArticle-
dc.citation.titleAnimal Cells and Systems-
dc.citation.number1-
dc.citation.endPage21-
dc.citation.startPage15-
dc.citation.volume12-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.alternativeNameNan-
dc.contributor.alternativeName맹오기-
dc.contributor.alternativeName신효정-
dc.contributor.alternativeName안현정-
dc.contributor.alternativeName염영일-
dc.contributor.alternativeName이해영-
dc.contributor.alternativeName백상기-
dc.identifier.bibliographicCitationAnimal Cells and Systems, vol. 12, no. 1, pp. 15-21-
dc.identifier.doi10.1080/19768354.2008.9647149-
dc.subject.keywordnitric oxide-
dc.subject.keywordmicroarray-
dc.subject.keywordmouse macrophage RAW264.7 cells-
dc.subject.keywordapoptosis-
dc.subject.localnitric oxide-
dc.subject.localNitric oxide (NO)-
dc.subject.localmicroarray-
dc.subject.localmouse macrophage RAW264.7 cells-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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