Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis = 오보바톨의 항암효과

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Title
Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis = 오보바톨의 항암효과
Author(s)
Su Kyung Lee; Hye Nan Kim; Yeong-Rim Kang; Chang Woo Lee; Hwan Mook Kim; Dong Cho Han; J Shin; K Bae; Byoung-Mog Kwon
Bibliographic Citation
Bioorganic & Medicinal Chemistry, vol. 16, no. 17, pp. 8397-8402
Publication Year
2008
Abstract
Neolignans such as obovatol, honokiol, and magnolol have been previously reported to show various biological activities including anti-inflammation and antitumor effects. This is the first demonstration on the in vivo antitumor effect of obovatol on human colorectal carcinoma SW620 cells. Nude mice were implanted with SW620 cells and fed with vehicle or 5 mg/kg/d dose of obovatol for 20 days. Obovatol inhibited tumor growth that accounted for 50% decrease in tumor volume and 44.6% decrease in tumor weight at the end of the experiment without any adverse health effect. In nude mice bearing SW620-incubated tumor, obovatol exhibited more potent antitumor activity than honolkiol. In addition, DNA flow cytometric analysis shows that obovatol progresses to apoptosis as detected by flow cytometry after double staining with annexin V and propidium iodide. Thus, we suggest that obovatol is a potent inducer of cell apoptosis in SW620 cells, and a potent antitumor agent.
Keyword
AntitumorApoptosisHonokiolMagnolia obovata ThunbObovatol
ISSN
0968-0896
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmc.2008.08.033
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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