Computational identification of significantly regulated metabolic reactions by integration of data on enzyme activity and gene expression

Cited 0 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorH Nam-
dc.contributor.authorTaewoo Ryu-
dc.contributor.authorK Lee-
dc.contributor.authorS Kim-
dc.contributor.authorD Lee-
dc.date.accessioned2017-04-19T09:11:41Z-
dc.date.available2017-04-19T09:11:41Z-
dc.date.issued2008-
dc.identifier.issn12258687-
dc.identifier.uri10.5483/BMBRep.2008.41.8.609ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8588-
dc.description.abstractThe concentrations and catalytic activities of enzymes control metabolic rates. Previous studies have focused on enzyme concentrations because there are no genome-wide techniques used for the measurement of enzyme activity. We propose a method for evaluating the significance of enzyme activity by integrating metabolic network topologies and genome-wide microarray gene expression profiles. We quantified the enzymatic activity of reactions and report the 388 significant reactions in five perturbation datasets. For the 388 enzymatic reactions, we identified 70 that were significantly regulated (P-value < 0.001). Thirty-one of these reactions were part of anaerobic metabolism, 23 were part of low-pH aerobic metabolism, 8 were part of high-pH anaerobic metabolism, 3 were part of low-pH aerobic reactions, and 5 were part of high-pH anaerobic metabolism.-
dc.publisherSouth Korea-
dc.titleComputational identification of significantly regulated metabolic reactions by integration of data on enzyme activity and gene expression-
dc.title.alternativeComputational identification of significantly regulated metabolic reactions by integration of data on enzyme activity and gene expression-
dc.typeArticle-
dc.citation.titleBMB Reports-
dc.citation.number8-
dc.citation.endPage614-
dc.citation.startPage609-
dc.citation.volume41-
dc.contributor.alternativeName남호정-
dc.contributor.alternativeName유태우-
dc.contributor.alternativeName이기영-
dc.contributor.alternativeName김상우-
dc.contributor.alternativeName이도헌-
dc.identifier.bibliographicCitationBMB Reports, vol. 41, no. 8, pp. 609-614-
dc.identifier.doi10.5483/BMBRep.2008.41.8.609-
dc.subject.keywordEnzyme activity-
dc.subject.keywordGene expression-
dc.subject.keywordMetabolic reaction-
dc.subject.keywordMetabolism regulation-
dc.subject.localEnzyme activity-
dc.subject.localGene expression-
dc.subject.localMetabolic reaction-
dc.subject.localMetabolism regulation-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.