DC Field | Value | Language |
---|---|---|
dc.contributor.author | H Nam | - |
dc.contributor.author | Taewoo Ryu | - |
dc.contributor.author | K Lee | - |
dc.contributor.author | S Kim | - |
dc.contributor.author | D Lee | - |
dc.date.accessioned | 2017-04-19T09:11:41Z | - |
dc.date.available | 2017-04-19T09:11:41Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1225-8687 | - |
dc.identifier.uri | 10.5483/BMBRep.2008.41.8.609 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8588 | - |
dc.description.abstract | The concentrations and catalytic activities of enzymes control metabolic rates. Previous studies have focused on enzyme concentrations because there are no genome-wide techniques used for the measurement of enzyme activity. We propose a method for evaluating the significance of enzyme activity by integrating metabolic network topologies and genome-wide microarray gene expression profiles. We quantified the enzymatic activity of reactions and report the 388 significant reactions in five perturbation datasets. For the 388 enzymatic reactions, we identified 70 that were significantly regulated (P-value < 0.001). Thirty-one of these reactions were part of anaerobic metabolism, 23 were part of low-pH aerobic metabolism, 8 were part of high-pH anaerobic metabolism, 3 were part of low-pH aerobic reactions, and 5 were part of high-pH anaerobic metabolism. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Computational identification of significantly regulated metabolic reactions by integration of data on enzyme activity and gene expression | - |
dc.title.alternative | Computational identification of significantly regulated metabolic reactions by integration of data on enzyme activity and gene expression | - |
dc.type | Article | - |
dc.citation.title | BMB Reports | - |
dc.citation.number | 8 | - |
dc.citation.endPage | 614 | - |
dc.citation.startPage | 609 | - |
dc.citation.volume | 41 | - |
dc.contributor.affiliatedAuthor | Taewoo Ryu | - |
dc.contributor.alternativeName | 남호정 | - |
dc.contributor.alternativeName | 유태우 | - |
dc.contributor.alternativeName | 이기영 | - |
dc.contributor.alternativeName | 김상우 | - |
dc.contributor.alternativeName | 이도헌 | - |
dc.identifier.bibliographicCitation | BMB Reports, vol. 41, no. 8, pp. 609-614 | - |
dc.identifier.doi | 10.5483/BMBRep.2008.41.8.609 | - |
dc.subject.keyword | Enzyme activity | - |
dc.subject.keyword | Gene expression | - |
dc.subject.keyword | Metabolic reaction | - |
dc.subject.keyword | Metabolism regulation | - |
dc.subject.local | Enzyme activities | - |
dc.subject.local | Enzyme activity | - |
dc.subject.local | enzyme activities | - |
dc.subject.local | enzyme activity | - |
dc.subject.local | Gene Expression | - |
dc.subject.local | Gene expression | - |
dc.subject.local | gene expression | - |
dc.subject.local | Metabolic reaction | - |
dc.subject.local | Metabolism regulation | - |
dc.description.journalClass | Y | - |
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