DC Field | Value | Language |
---|---|---|
dc.contributor.author | J H Kwak | - |
dc.contributor.author | K Namgoong | - |
dc.contributor.author | J K Jung | - |
dc.contributor.author | Jungsook Cho | - |
dc.contributor.author | Hwan Mook Kim | - |
dc.contributor.author | Song Kyu Park | - |
dc.contributor.author | Young Ah Yoo | - |
dc.contributor.author | Joo Hee Kwon | - |
dc.contributor.author | H Lee | - |
dc.date.accessioned | 2017-04-19T09:11:42Z | - |
dc.date.available | 2017-04-19T09:11:42Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | 10.1007/s12272-001-1258-6 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8594 | - |
dc.description.abstract | A series of 2-alkyl-2,3-dihydro-1H-2,6,9-triazacyclopenta[b]anthracene-5, 10-diones (4a-f) were synthesized and their in vitro cytotoxic activities were evaluated against six human cancer cell lines (HCT15, SK-OV-3, A549, SNB19, MCF7 and MCF7/ADR). A number of compounds including 4c and 4d showed 2-180 times more potent cytotoxic activity than doxorubicin against all human cancer cell lines tested. Furthermore, these compounds retained considerable cytotoxic activity against the doxorubicin-resistant cell line MCF7/ADR, implying their therapeutic potential to treat doxorubicin-resistant tumors. | - |
dc.publisher | Pharmaceutical Soc Korea | - |
dc.title | Synthesis and cytotoxic activities of 2-alkyl-2,3-dihydro-1H-2,6,9-tri-azacyclopenta[b]anthracene-5,10-dions | - |
dc.title.alternative | Synthesis and cytotoxic activities of 2-alkyl-2,3-dihydro-1H-2,6,9-tri-azacyclopenta[b]anthracene-5,10-dions | - |
dc.type | Article | - |
dc.citation.title | Archives of Pharmacal Research | - |
dc.citation.number | 8 | - |
dc.citation.endPage | 998 | - |
dc.citation.startPage | 995 | - |
dc.citation.volume | 31 | - |
dc.contributor.affiliatedAuthor | Hwan Mook Kim | - |
dc.contributor.affiliatedAuthor | Song Kyu Park | - |
dc.contributor.affiliatedAuthor | Young Ah Yoo | - |
dc.contributor.affiliatedAuthor | Joo Hee Kwon | - |
dc.contributor.alternativeName | 곽재환 | - |
dc.contributor.alternativeName | 남궁권 | - |
dc.contributor.alternativeName | 정재경 | - |
dc.contributor.alternativeName | 조정숙 | - |
dc.contributor.alternativeName | 김환묵 | - |
dc.contributor.alternativeName | 박성규 | - |
dc.contributor.alternativeName | 유영아 | - |
dc.contributor.alternativeName | 권주희 | - |
dc.contributor.alternativeName | 이희순 | - |
dc.identifier.bibliographicCitation | Archives of Pharmacal Research, vol. 31, no. 8, pp. 995-998 | - |
dc.identifier.doi | 10.1007/s12272-001-1258-6 | - |
dc.subject.keyword | Cytotoxic activity | - |
dc.subject.keyword | Triazacyclopenta[b]anthracene-5,10-diones | - |
dc.subject.local | cytotoxic activities | - |
dc.subject.local | cytotoxic activity | - |
dc.subject.local | Cytotoxic activity | - |
dc.subject.local | Triazacyclopenta[b]anthracene-5,10-diones | - |
dc.description.journalClass | Y | - |
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