Fission yeast-based screening to identify putative HDAC inhibitors using a telomeric reporter strain = 분열효모 시스템의 텔로머릭 리포터 균주를 이용한 HDAC 저해제 스크리닝

Cited 0 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorKyung Sook Chung-
dc.contributor.authorJiwon Ahn-
dc.contributor.authorJeong Hae Choi-
dc.contributor.authorN H Yim-
dc.contributor.authorC M Kang-
dc.contributor.authorC H Kim-
dc.contributor.authorKyeong Lee-
dc.contributor.authorH M Park-
dc.contributor.authorK B Song-
dc.contributor.authorMi Sun Won-
dc.date.accessioned2017-04-19T09:11:43Z-
dc.date.available2017-04-19T09:11:43Z-
dc.date.issued2008-
dc.identifier.issn10168478-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8601-
dc.description.abstractTranscriptional silencing is regulated by promoter methylation and histone modifications such as methylation and acetylation. We constructed a Schizosaccaromyces pombe reporter strain, KCT120a, to identify modifiers of transcriptional silencing, by inserting the ura4+ gene into a heterochromatic telomere region. Two compounds inhibited the activity of histone deacetylases, induced acetylation of histone H3 and caused apoptotic cell death in HeLa cells. Expression of gelsolin and p21waf1/cip1 also increased, as it does in response to HDAC inhibitors such as TSA. Therefore, these compounds appear to be potent inhibitors of HDACs, and hence potential anti-cancer drugs. Our observations suggest that a yeast cell-based assay system for transcriptional silencing may be useful for identifying histone deacetylase inhibitors and other agents affecting chromatin remodeling.-
dc.publisherSouth Korea-
dc.titleFission yeast-based screening to identify putative HDAC inhibitors using a telomeric reporter strain = 분열효모 시스템의 텔로머릭 리포터 균주를 이용한 HDAC 저해제 스크리닝-
dc.title.alternativeFission yeast-based screening to identify putative HDAC inhibitors using a telomeric reporter strain-
dc.typeArticle-
dc.citation.titleMolecules and Cells-
dc.citation.number1-
dc.citation.endPage99-
dc.citation.startPage93-
dc.citation.volume26-
dc.contributor.affiliatedAuthorKyung Sook Chung-
dc.contributor.affiliatedAuthorJiwon Ahn-
dc.contributor.affiliatedAuthorMi Sun Won-
dc.contributor.alternativeName정경숙-
dc.contributor.alternativeName안지원-
dc.contributor.alternativeName최정해-
dc.contributor.alternativeName임남희-
dc.contributor.alternativeName강창모-
dc.contributor.alternativeName김천호-
dc.contributor.alternativeName이경-
dc.contributor.alternativeName박희문-
dc.contributor.alternativeName송경빈-
dc.contributor.alternativeName원미선-
dc.identifier.bibliographicCitationMolecules and Cells, vol. 26, no. 1, pp. 93-99-
dc.subject.keywordHDAC inhibitor-
dc.subject.keywordheterochromatin-
dc.subject.keywordschizosaccharomyces pombe-
dc.subject.keywordtelomere-
dc.subject.keywordyeast-drug screen-
dc.subject.localHDAC inhibitor-
dc.subject.localheterochromatin-
dc.subject.localschizosaccharomyces pombe-
dc.subject.localSchizosaccharomyces pombe-
dc.subject.localtelomere-
dc.subject.localyeast-drug screen-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > 1. Journal Articles
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.