An anti-viral peptide derived from the preS1 surface protein of hepatitis B virus

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Title
An anti-viral peptide derived from the preS1 surface protein of hepatitis B virus
Author(s)
D H Kim; Y Ni; Si Hyung Lee; S Urban; Kyou Hoon Han
Bibliographic Citation
BMB Reports, vol. 41, no. 9, pp. 640-644
Publication Year
2008
Abstract
The preS1 surface protein of the hepatitis B virus (HBV) is a key factor involved in initial viral entry into hepatocytes. It has been long postulated that an anti-HBV effect should be achievable using peptide fragments of the preSl. Recent reports demonstrated that several preSl -derived lipo-peptides in genotype D HBV exhibit nano to picomolar inhibitory activity against HBV infection. In this study, an acylated analog of a preS1 fragment, a 21-residue lipo-peptide (named 7524 BVS7) with a sequence of palmitoyl- GMGTNLSVPNPLGFFPDHQLDC-NH2, from genotype C HBV was produced base upon a previous structural study and was shown potently inhibits HBV infection with an IC50 of ? 20 nM.
Keyword
hepatitis B virus (HBV)intrinsically unstructured protein (IUP)lipo-peptideslocal pre-structured motifnuclear magnetic resonance (Nmr)preSl
ISSN
1225-8687
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5483/BMBRep.2008.41.9.640
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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