Epigallocatechin gallate stimulates glucose uptake through the phosphatidylinositol 3-kinase-mediated pathway in L6 rat skeletal muscle cells = Epigallocatechin gallate는 L6마우스 골근세포 phosphatidylinositol 3-kinase-mediated pathway통해 포도당흡수 촉진

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dc.contributor.authorK H Jung-
dc.contributor.authorH S Choi-
dc.contributor.authorD H Kim-
dc.contributor.authorM Y Han-
dc.contributor.authorU J Chang-
dc.contributor.authorS V Yim-
dc.contributor.authorB C Song-
dc.contributor.authorChul Ho Kim-
dc.contributor.authorS A Kang-
dc.date.accessioned2017-04-19T09:11:48Z-
dc.date.available2017-04-19T09:11:48Z-
dc.date.issued2008-
dc.identifier.issn1096-620X-
dc.identifier.uri10.1089/jmf.2007.0107ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8612-
dc.description.abstractThe effect of epigallocatechin gallate (EGCG) on glucose uptake was studied in L6 rat skeletal muscle cells. Glucose uptake assay revealed that EGCG increased glucose uptake >70% compared to control. EGCG-stimulated glucose uptake was blocked by LY294002, an inhibitor of phosphatidylinositol (PI) 3-kinase, which is a major regulatory molecule in glucose uptake pathways. However, AMP-activated protein kinase (AMPK), which is another crucial mediator in independent glucose uptake pathways, did not inhibit EGCG-stimulated glucose uptake by SB203585, a specific inhibitor of the AMPK downstream mediator, p38 mitogen-activated protein kinase (MAPK). We also found that EGCG increased the phosphorylation level of protein kinase B and PI 3-kinase activity, when assessed by PI 3-kinase assay, whereas no increase in the phosphorylation level of AMPK and p38 MAPK was observed. Taken together, these results suggest that EGCG might stimulate glucose uptake, not AMPK-mediated but PI 3-kinase-mediated, in skeletal muscle cells, thereby contributing to glucose homeostasis.-
dc.publisherMary Ann Liebert, Inc-
dc.titleEpigallocatechin gallate stimulates glucose uptake through the phosphatidylinositol 3-kinase-mediated pathway in L6 rat skeletal muscle cells = Epigallocatechin gallate는 L6마우스 골근세포 phosphatidylinositol 3-kinase-mediated pathway통해 포도당흡수 촉진-
dc.title.alternativeEpigallocatechin gallate stimulates glucose uptake through the phosphatidylinositol 3-kinase-mediated pathway in L6 rat skeletal muscle cells-
dc.typeArticle-
dc.citation.titleJournal of Medicinal Food-
dc.citation.number3-
dc.citation.endPage434-
dc.citation.startPage429-
dc.citation.volume11-
dc.contributor.affiliatedAuthorChul Ho Kim-
dc.contributor.alternativeName정경희-
dc.contributor.alternativeName최한성-
dc.contributor.alternativeName김동환-
dc.contributor.alternativeName한미영-
dc.contributor.alternativeName장은재-
dc.contributor.alternativeName임성빈-
dc.contributor.alternativeName송병천-
dc.contributor.alternativeName김철호-
dc.contributor.alternativeName강순아-
dc.identifier.bibliographicCitationJournal of Medicinal Food, vol. 11, no. 3, pp. 429-434-
dc.identifier.doi10.1089/jmf.2007.0107-
dc.subject.keywordAMP-activated protein kinase-
dc.subject.keywordEpigallocatechin gallate-
dc.subject.keywordGlucose uptake-
dc.subject.keywordPhosphatidylinositol 3-kinase-
dc.subject.keywordSkeletal muscle-
dc.subject.localAMP-activated protein kinase (AMPK)-
dc.subject.localAMP-activated protein kinase-
dc.subject.localEpigallocatechin gallate-
dc.subject.localGlucose uptake-
dc.subject.localglucose uptake-
dc.subject.localGlucose-uptake-
dc.subject.localPhosphatidylinositol 3-kinase-
dc.subject.localskeletal muscle-
dc.subject.localSkeletal muscle-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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