DC Field | Value | Language |
---|---|---|
dc.contributor.author | K H Jung | - |
dc.contributor.author | H S Choi | - |
dc.contributor.author | D H Kim | - |
dc.contributor.author | M Y Han | - |
dc.contributor.author | U J Chang | - |
dc.contributor.author | S V Yim | - |
dc.contributor.author | B C Song | - |
dc.contributor.author | Chul Ho Kim | - |
dc.contributor.author | S A Kang | - |
dc.date.accessioned | 2017-04-19T09:11:48Z | - |
dc.date.available | 2017-04-19T09:11:48Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | 10.1089/jmf.2007.0107 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8612 | - |
dc.description.abstract | The effect of epigallocatechin gallate (EGCG) on glucose uptake was studied in L6 rat skeletal muscle cells. Glucose uptake assay revealed that EGCG increased glucose uptake >70% compared to control. EGCG-stimulated glucose uptake was blocked by LY294002, an inhibitor of phosphatidylinositol (PI) 3-kinase, which is a major regulatory molecule in glucose uptake pathways. However, AMP-activated protein kinase (AMPK), which is another crucial mediator in independent glucose uptake pathways, did not inhibit EGCG-stimulated glucose uptake by SB203585, a specific inhibitor of the AMPK downstream mediator, p38 mitogen-activated protein kinase (MAPK). We also found that EGCG increased the phosphorylation level of protein kinase B and PI 3-kinase activity, when assessed by PI 3-kinase assay, whereas no increase in the phosphorylation level of AMPK and p38 MAPK was observed. Taken together, these results suggest that EGCG might stimulate glucose uptake, not AMPK-mediated but PI 3-kinase-mediated, in skeletal muscle cells, thereby contributing to glucose homeostasis. | - |
dc.publisher | Mary Ann Liebert, Inc | - |
dc.title | Epigallocatechin gallate stimulates glucose uptake through the phosphatidylinositol 3-kinase-mediated pathway in L6 rat skeletal muscle cells = Epigallocatechin gallate는 L6마우스 골근세포 phosphatidylinositol 3-kinase-mediated pathway통해 포도당흡수 촉진 | - |
dc.title.alternative | Epigallocatechin gallate stimulates glucose uptake through the phosphatidylinositol 3-kinase-mediated pathway in L6 rat skeletal muscle cells | - |
dc.type | Article | - |
dc.citation.title | Journal of Medicinal Food | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 434 | - |
dc.citation.startPage | 429 | - |
dc.citation.volume | 11 | - |
dc.contributor.affiliatedAuthor | Chul Ho Kim | - |
dc.contributor.alternativeName | 정경희 | - |
dc.contributor.alternativeName | 최한성 | - |
dc.contributor.alternativeName | 김동환 | - |
dc.contributor.alternativeName | 한미영 | - |
dc.contributor.alternativeName | 장은재 | - |
dc.contributor.alternativeName | 임성빈 | - |
dc.contributor.alternativeName | 송병천 | - |
dc.contributor.alternativeName | 김철호 | - |
dc.contributor.alternativeName | 강순아 | - |
dc.identifier.bibliographicCitation | Journal of Medicinal Food, vol. 11, no. 3, pp. 429-434 | - |
dc.identifier.doi | 10.1089/jmf.2007.0107 | - |
dc.subject.keyword | AMP-activated protein kinase | - |
dc.subject.keyword | Epigallocatechin gallate | - |
dc.subject.keyword | Glucose uptake | - |
dc.subject.keyword | Phosphatidylinositol 3-kinase | - |
dc.subject.keyword | Skeletal muscle | - |
dc.subject.local | AMP-activated protein kinase (AMPK) | - |
dc.subject.local | AMP-activated protein kinase | - |
dc.subject.local | Epigallocatechin gallate | - |
dc.subject.local | Glucose uptake | - |
dc.subject.local | glucose uptake | - |
dc.subject.local | Glucose-uptake | - |
dc.subject.local | Phosphatidylinositol 3-kinase | - |
dc.subject.local | skeletal muscle | - |
dc.subject.local | Skeletal muscle | - |
dc.description.journalClass | Y | - |
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