Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT

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Title
Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT
Author(s)
D O Moon; Mun-Ock Kim; Y H Choi; Hee Gu Lee; N D Kim; G Y Kim
Bibliographic Citation
FEBS Letters, vol. 582, no. 23, pp. 3367-3373
Publication Year
2008
Abstract
Gossypol is a polyphenolic compound originally isolated from cottonseed that has long been used successfully as a contraceptive drug for males. However, the molecular mechanism of anti-telomerase effects of gossypol is not entirely understood. In this study, we observed direct cytotoxicity and inhibition of telomerase activity with downregulation of telomerase reverse transcriptase (hTERT) expression. Gossypol treatment resulted in a decrease of c-Myc expression and binding activity. Gossypol treatment also suppressed the activation of Akt, thereby inhibiting hTERT phosphorylation and translocation into the nucleus. We conclude that gossypol regulates the loss of telomerase activity through transcriptional and posttranslational modifications of hTERT.
Keyword
Aktc-MycGossypolhTERTTelomerase
ISSN
0014-5793
Publisher
Wiley
DOI
http://dx.doi.org/10.1016/j.febslet.2008.08.029
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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