A new antioxidant, clitocybin A, from the culture broth of Clitocybe aurantiaca

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Title
A new antioxidant, clitocybin A, from the culture broth of Clitocybe aurantiaca
Author(s)
Young Hee Kim; S M Cho; J W Hyun; In Ja Ryoo; Soo-Jin Choo; Sangku Lee; S J Seok; J S Hwang; E D Sohn; B S Yun; K H Bae; Ick Dong Yoo
Bibliographic Citation
Journal of Antibiotics, vol. 61, no. 9, pp. 573-576
Publication Year
2008
Abstract
Clitocybin A (1), a new antioxidant, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography and preparative HPLC. Its structure was determined as 4,6-dihydroxy-2-ρ-hydroxyphenyl- isoindol-1-one on the basis of the UV, NMR, and MS spectroscopic analysis. The compound 1 showed potent free radical scavenging activity against superoxide, ABTS, and DPPH radicals, and protective effect against cellular DNA damage induced by oxidative stress.
Keyword
antioxidant activityclitocybe aurantiacaclitocybin Acomet assay
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/ja.2008.77
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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