A new antioxidant, clitocybin A, from the culture broth of Clitocybe aurantiaca
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- Title
- A new antioxidant, clitocybin A, from the culture broth of Clitocybe aurantiaca
- Author(s)
- Young Hee Kim; S M Cho; J W Hyun; In Ja Ryoo; Soo-Jin Choo; Sangku Lee; S J Seok; J S Hwang; E D Sohn; B S Yun; K H Bae; Ick Dong Yoo
- Bibliographic Citation
- Journal of Antibiotics, vol. 61, no. 9, pp. 573-576
- Publication Year
- 2008
- Abstract
- Clitocybin A (1), a new antioxidant, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography and preparative HPLC. Its structure was determined as 4,6-dihydroxy-2-ρ-hydroxyphenyl- isoindol-1-one on the basis of the UV, NMR, and MS spectroscopic analysis. The compound 1 showed potent free radical scavenging activity against superoxide, ABTS, and DPPH radicals, and protective effect against cellular DNA damage induced by oxidative stress.
- ISSN
- 0021-8820
- Publisher
- Springer-Nature Pub Group
- Full Text Link
- http://dx.doi.org/10.1038/ja.2008.77
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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