Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast

Cited 282 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorA Roguev-
dc.contributor.authorS Bandyopadhyay-
dc.contributor.authorM Zofall-
dc.contributor.authorK Zhang-
dc.contributor.authorT Fischer-
dc.contributor.authorS R Collins-
dc.contributor.authorH Qu-
dc.contributor.authorM Shales-
dc.contributor.authorH O Park-
dc.contributor.authorJ Hayles-
dc.contributor.authorKwang Lae Hoe-
dc.contributor.authorDong Uk Kim-
dc.contributor.authorT Ideker-
dc.contributor.authorS I Grewal-
dc.contributor.authorJ S Weissman-
dc.contributor.authorN J Krogan-
dc.date.accessioned2017-04-19T09:11:57Z-
dc.date.available2017-04-19T09:11:57Z-
dc.date.issued2008-
dc.identifier.issn0036-8075-
dc.identifier.uri10.1126/science.1162609ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8647-
dc.description.abstractAn epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces pombe, by systematically measuring the phenotypes associated with pairs of mutations. This high-density, quantitative genetic interaction map focused on various aspects of chromosome function, including transcription regulation and DNA repair/replication. The E-MAP uncovered a previously unidentified component of the RNA interference (RNAi) machinery (rsh1) and linked the RNAi pathway to several other biological processes. Comparison of the S. pombe E-MAP to an analogous genetic map from the budding yeast revealed that, whereas negative interactions were conserved between genes involved in similar biological processes, positive interactions and overall genetic profiles between pairs of genes coding for physically associated proteins were even more conserved. Hence, conservation occurs at the level of the functional module (protein complex), but the genetic cross talk between modules can differ substantially.-
dc.publisherAmer Assoc Advancement Science-
dc.titleConservation and rewiring of functional modules revealed by an epistasis map in fission yeast-
dc.title.alternativeConservation and rewiring of functional modules revealed by an epistasis map in fission yeast-
dc.typeArticle-
dc.citation.titleScience-
dc.citation.number5900-
dc.citation.endPage410-
dc.citation.startPage405-
dc.citation.volume322-
dc.contributor.affiliatedAuthorKwang Lae Hoe-
dc.contributor.affiliatedAuthorDong Uk Kim-
dc.contributor.alternativeNameRoguev-
dc.contributor.alternativeNameBandyopadhyay-
dc.contributor.alternativeNameZofall-
dc.contributor.alternativeNameZhang-
dc.contributor.alternativeNameFischer-
dc.contributor.alternativeNameCollins-
dc.contributor.alternativeNameQu-
dc.contributor.alternativeNameShales-
dc.contributor.alternativeName박한오-
dc.contributor.alternativeNameHayles-
dc.contributor.alternativeName허광래-
dc.contributor.alternativeName김동욱-
dc.contributor.alternativeNameIdeker-
dc.contributor.alternativeNameGrewal-
dc.contributor.alternativeNameWeissman-
dc.contributor.alternativeNameKrogan-
dc.identifier.bibliographicCitationScience, vol. 322, no. 5900, pp. 405-410-
dc.identifier.doi10.1126/science.1162609-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.