Penicillium griseofulvum F1959, high-production strain of pyripyropene A, specific inhibitor of Acyl-CoA: cholesterol acyltransferase 2

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Title
Penicillium griseofulvum F1959, high-production strain of pyripyropene A, specific inhibitor of Acyl-CoA: cholesterol acyltransferase 2
Author(s)
Jung Ho Choi; Mun Chual RhoSeung Woong Lee; Ji Na Choi; Hee Jeong Lee; Kyung Sook Bae; K Kim; Young Kook Kim
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 18, no. 10, pp. 1663-1665
Publication Year
2008
Abstract
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) catalyzes cholesterol esterification and plays an important role in the intestinal absorption of cholesterol, hepatic production of lipoproteins, and accumulation of cholesteryl ester within cells. During the course of screening to find ACAT inhibitors from microbial sources, the present authors isolated pyripyropene A from Penicillium griseofulvum F1959. Pyripyropene A, an ACAT2-specific inhibitor, has already been produced from Aspergillus fumigatus. Yet, Aspergillus fumigatus is a pathogen and only produces a limited amount of pyripyropene A, making the isolation of pyripyropene A troublesome. In contrast, Penicillium griseofulvum F1959 was found to produce approximately 28 times more pyripyropene A than Aspergillus fumigatus, plus this report also describes the ideal conditions for the production of pyripyropene A by Penicillium griseofulvum F1959 and its subsequent purification.
Keyword
acyl-coenzyme Aatherosclerosischolesterol acyltransferase (ACAT)penicillium griseofulvum F1959pyripyropene A
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
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