Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice

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dc.contributor.authorJong Soon Kang-
dc.contributor.authorWoon Kee Yoon-
dc.contributor.authorJ K Youm-
dc.contributor.authorS K Jeong-
dc.contributor.authorB D Park-
dc.contributor.authorM H Han-
dc.contributor.authorHuen Ju Lee-
dc.contributor.authorE Y Moon-
dc.contributor.authorS B Han-
dc.contributor.authorChang Woo Lee-
dc.contributor.authorKiho Lee-
dc.contributor.authorSong Kyu Park-
dc.contributor.authorK H Yang-
dc.contributor.authorHwan Mook Kim-
dc.date.accessioned2017-04-19T09:12:00Z-
dc.date.available2017-04-19T09:12:00Z-
dc.date.issued2008-
dc.identifier.issn0906-6705-
dc.identifier.uri10.1111/j.1600-0625.2008.00737.xko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8656-
dc.description.abstractAtopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in childhood. K6PC-9p (N -(Ethyl dihydrogenphosphate)-2-hexyl-3-oxo-decanamide) is a synthetic ceramide derivative of PC-9S (N -Ethanol-2-mirystyl-3-oxo-staramide), which was known to be effective in atopic patients. In this study, we examined the effect of topical application of K6PC-9p on skin inflammation and AD-like skin lesions in mouse models. K6PC-9p dose-dependently inhibited phorbol ester-induced increase in ear thickness in BALB/c mice. Moreover, topical application of K6PC-9p suppressed dust mite extract-induced AD-like skin lesions in NC/Nga mice. Histopathological analysis revealed that both ear swelling and leucocyte infiltration were suppressed by K6PC-9p treatment. K6PC-9p also suppressed IL-4 and TNF-α expression in the ears and mast cell infiltration into the ears in NC/Nga mice. Further study demonstrated that K6PC-9p inhibited ConA-induced IL-4 secretion and LPS-induced macrophage activation. Taken together, our results showed that topical application of K6PC-9p exerts beneficial effects in animal model of skin inflammation and AD, suggesting that K6PC-9p might be a promising topical agent for the treatment of inflammatory skin diseases.-
dc.publisherWiley-
dc.titleInhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice-
dc.title.alternativeInhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice-
dc.typeArticle-
dc.citation.titleExperimental Dermatology-
dc.citation.number11-
dc.citation.endPage964-
dc.citation.startPage958-
dc.citation.volume17-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.affiliatedAuthorWoon Kee Yoon-
dc.contributor.affiliatedAuthorHuen Ju Lee-
dc.contributor.affiliatedAuthorChang Woo Lee-
dc.contributor.affiliatedAuthorKiho Lee-
dc.contributor.affiliatedAuthorSong Kyu Park-
dc.contributor.affiliatedAuthorHwan Mook Kim-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName윤원기-
dc.contributor.alternativeName염종경-
dc.contributor.alternativeName정세교-
dc.contributor.alternativeName박병덕-
dc.contributor.alternativeName한미화-
dc.contributor.alternativeName이현주-
dc.contributor.alternativeName문은이-
dc.contributor.alternativeName한상배-
dc.contributor.alternativeName이창우-
dc.contributor.alternativeName이기호-
dc.contributor.alternativeName박성규-
dc.contributor.alternativeName양규환-
dc.contributor.alternativeName김환묵-
dc.identifier.bibliographicCitationExperimental Dermatology, vol. 17, no. 11, pp. 958-964-
dc.identifier.doi10.1111/j.1600-0625.2008.00737.x-
dc.subject.keywordAtopic dermatitis-
dc.subject.keywordDust mite-
dc.subject.keywordK6PC-9p-
dc.subject.keywordNC/Nga-
dc.subject.keywordSkin inflammation-
dc.subject.localAtopic Dermatitis-
dc.subject.localAtopic dermatitis-
dc.subject.localatopic dermatitis (AD)-
dc.subject.localatopic dermatitis-
dc.subject.localDust mite-
dc.subject.localK6PC-9p-
dc.subject.localNC/Nga-
dc.subject.localSkin inflammation-
dc.subject.localskin inflammation-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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