DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jong Soon Kang | - |
dc.contributor.author | Woon Kee Yoon | - |
dc.contributor.author | J K Youm | - |
dc.contributor.author | S K Jeong | - |
dc.contributor.author | B D Park | - |
dc.contributor.author | M H Han | - |
dc.contributor.author | Huen Ju Lee | - |
dc.contributor.author | E Y Moon | - |
dc.contributor.author | S B Han | - |
dc.contributor.author | Chang Woo Lee | - |
dc.contributor.author | Kiho Lee | - |
dc.contributor.author | Song Kyu Park | - |
dc.contributor.author | K H Yang | - |
dc.contributor.author | Hwan Mook Kim | - |
dc.date.accessioned | 2017-04-19T09:12:00Z | - |
dc.date.available | 2017-04-19T09:12:00Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.uri | 10.1111/j.1600-0625.2008.00737.x | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8656 | - |
dc.description.abstract | Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in childhood. K6PC-9p (N -(Ethyl dihydrogenphosphate)-2-hexyl-3-oxo-decanamide) is a synthetic ceramide derivative of PC-9S (N -Ethanol-2-mirystyl-3-oxo-staramide), which was known to be effective in atopic patients. In this study, we examined the effect of topical application of K6PC-9p on skin inflammation and AD-like skin lesions in mouse models. K6PC-9p dose-dependently inhibited phorbol ester-induced increase in ear thickness in BALB/c mice. Moreover, topical application of K6PC-9p suppressed dust mite extract-induced AD-like skin lesions in NC/Nga mice. Histopathological analysis revealed that both ear swelling and leucocyte infiltration were suppressed by K6PC-9p treatment. K6PC-9p also suppressed IL-4 and TNF-α expression in the ears and mast cell infiltration into the ears in NC/Nga mice. Further study demonstrated that K6PC-9p inhibited ConA-induced IL-4 secretion and LPS-induced macrophage activation. Taken together, our results showed that topical application of K6PC-9p exerts beneficial effects in animal model of skin inflammation and AD, suggesting that K6PC-9p might be a promising topical agent for the treatment of inflammatory skin diseases. | - |
dc.publisher | Wiley | - |
dc.title | Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice | - |
dc.title.alternative | Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice | - |
dc.type | Article | - |
dc.citation.title | Experimental Dermatology | - |
dc.citation.number | 11 | - |
dc.citation.endPage | 964 | - |
dc.citation.startPage | 958 | - |
dc.citation.volume | 17 | - |
dc.contributor.affiliatedAuthor | Jong Soon Kang | - |
dc.contributor.affiliatedAuthor | Woon Kee Yoon | - |
dc.contributor.affiliatedAuthor | Huen Ju Lee | - |
dc.contributor.affiliatedAuthor | Chang Woo Lee | - |
dc.contributor.affiliatedAuthor | Kiho Lee | - |
dc.contributor.affiliatedAuthor | Song Kyu Park | - |
dc.contributor.affiliatedAuthor | Hwan Mook Kim | - |
dc.contributor.alternativeName | 강종순 | - |
dc.contributor.alternativeName | 윤원기 | - |
dc.contributor.alternativeName | 염종경 | - |
dc.contributor.alternativeName | 정세교 | - |
dc.contributor.alternativeName | 박병덕 | - |
dc.contributor.alternativeName | 한미화 | - |
dc.contributor.alternativeName | 이현주 | - |
dc.contributor.alternativeName | 문은이 | - |
dc.contributor.alternativeName | 한상배 | - |
dc.contributor.alternativeName | 이창우 | - |
dc.contributor.alternativeName | 이기호 | - |
dc.contributor.alternativeName | 박성규 | - |
dc.contributor.alternativeName | 양규환 | - |
dc.contributor.alternativeName | 김환묵 | - |
dc.identifier.bibliographicCitation | Experimental Dermatology, vol. 17, no. 11, pp. 958-964 | - |
dc.identifier.doi | 10.1111/j.1600-0625.2008.00737.x | - |
dc.subject.keyword | Atopic dermatitis | - |
dc.subject.keyword | Dust mite | - |
dc.subject.keyword | K6PC-9p | - |
dc.subject.keyword | NC/Nga | - |
dc.subject.keyword | Skin inflammation | - |
dc.subject.local | Atopic Dermatitis | - |
dc.subject.local | Atopic dermatitis | - |
dc.subject.local | atopic dermatitis | - |
dc.subject.local | atopic dermatitis (AD) | - |
dc.subject.local | Atopic dermatitis (AD) | - |
dc.subject.local | Dust mite | - |
dc.subject.local | K6PC-9p | - |
dc.subject.local | NC/Nga | - |
dc.subject.local | Skin inflammation | - |
dc.subject.local | skin inflammation | - |
dc.description.journalClass | Y | - |
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