Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B

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dc.contributor.authorP T Thuong-
dc.contributor.authorChul Ho Lee-
dc.contributor.authorT T Dao-
dc.contributor.authorP H Nguyen-
dc.contributor.authorW G Kim-
dc.contributor.authorS J Lee-
dc.contributor.authorW K Oh-
dc.date.accessioned2017-04-19T09:12:01Z-
dc.date.available2017-04-19T09:12:01Z-
dc.date.issued2008-
dc.identifier.issn0163-3864-
dc.identifier.uri10.1021/np800298wko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8660-
dc.description.abstractPhytochemical study on a methanol-soluble extract of the leaves of persimmon (Diospyros kaki) resulted in the isolation of two new ursane-type triterpenoids, 3α,19α-dihydroxyurs-12,20(30)-dien-24,28-dioic acid (1) and 3α,19α-dihydroxyurs-12-en-24,28-dioic acid (2), together with 12 known ursane- and oleanane-type triterpenoids (3-14). Triterpenoids with a 3β-hydroxy group were found to inhibit protein tyrosine phosphatase 1B (PTP1B) activity, with IC50 values ranging from 3.1 ± 0.2 to 18.8 ± 1.3 μM, whereas those with a 3α-hydroxy moiety were not active.-
dc.publisherAmer Chem Soc-
dc.titleTriterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B-
dc.title.alternativeTriterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number10-
dc.citation.endPage1778-
dc.citation.startPage1775-
dc.citation.volume71-
dc.contributor.affiliatedAuthorChul Ho Lee-
dc.contributor.alternativeNameThuong-
dc.contributor.alternativeName이철호-
dc.contributor.alternativeNameDao-
dc.contributor.alternativeNameNguyen-
dc.contributor.alternativeName김완기-
dc.contributor.alternativeName이상준-
dc.contributor.alternativeName오원근-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 71, no. 10, pp. 1775-1778-
dc.identifier.doi10.1021/np800298w-
dc.description.journalClassY-
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Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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