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- Title
- Anti-inflammatory activity of methanolic extract isolated from immature fruit of Thus succedanea
- Author(s)
- Jong Soon Kang; Chang Woo Lee; Ki Hoon Lee; M H Han; H Lee; S B Han; Hyoung-Chin Kim; Kiho Lee; Song Kyu Park; Hwan Mook Kim
- Bibliographic Citation
- Laboratory Animal Research, vol. 24, no. 3, pp. 297-302
- Publication Year
- 2008
- Abstract
- In this study, we report the anti-inflammatory activity of methanolic extract isolated from immature fruit of Rhus succedanea (RS). RS dose-dependently inhibited lipopolysaccharide (LPS)-induced production of inflammatory mediators, such as interleukin-1β (IL-1β) and nitric oxide in RAW 264.7 cells, a murine macrophage-like cell line. The mRNA expressions of IL-1β and inducible nitric oxide synthase (iNOS) were also suppressed by RS in LPS-stimulated RAW 264.7 cells. Transient transfection and reporter gene assay demonstrated that LPS-induced NF-κB activity was significantly inhibited by RS in RAW 264.7 cells. Further study demonstrated that topical application of RS suppressed ear swelling in TPA-induced skin inflammation model. Moreover, RS also increased survival rate and time in animal model of sepsis. Collectively, these results suggest that RS exerts an anti-inflammatory effect in vitro and in vivo and this might be mediated, at least in part, by blocking NF-κB activation.
- Keyword
- Rhus succedaneainterleukin-1βnitric oxideNF-κB
- ISSN
- 1738-6055
- Publisher
- Springer-BMC
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
- Files in This Item:
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