Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo

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dc.contributor.authorL Y Guo-
dc.contributor.authorX F Cai-
dc.contributor.authorJung Joon Lee-
dc.contributor.authorS S Kang-
dc.contributor.authorE M Shin-
dc.contributor.authorH Y Zhou-
dc.contributor.authorJ W Jung-
dc.contributor.authorY S Kim-
dc.date.accessioned2017-04-19T09:12:04Z-
dc.date.available2017-04-19T09:12:04Z-
dc.date.issued2008-
dc.identifier.issn0253-6269-
dc.identifier.uri10.1007/s12272-001-1183-8ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/8670-
dc.description.abstractDemethoxycurcumin and bisdemethoxycurcumin are the main active ingredients isolated from Curcumae Longae Radix. Recent studies demonstrated that both compounds exhibit antioxidative and anti-inflammatory effects as well as effects on cancer cell lines. In this study, we compared the activities of demethoxycurcumin and bisdemethoxycurcumin, and both compounds were evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cycloxygenase-2 (COX-2) and nuclear factor-kappaB (NF-κB) activity in a RAW 264.7 macrophage cell line. The evaluation:results suggested that the anti-inflammatory properties of demethoxycurcumin and bisdemethoxycurcumin were attributed to the inhibition of iNOS and COX-2 expression, as initiated by the inhibition of NF-κB activity. Additionally, both of them significantly inhibited carrageenan-induced paw edema in mice. Taken together, all of the results showed that the suppressive effect of demethoxycurcumin was stronger than that of bisdemethoxycurcumin, indicating that the methoxy group had enhanced demethoxycurcumin's anti-inflammation effects.-
dc.publisherPharmaceutical Soc Korea-
dc.titleComparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo-
dc.title.alternativeComparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number4-
dc.citation.endPage496-
dc.citation.startPage490-
dc.citation.volume31-
dc.contributor.affiliatedAuthorJung Joon Lee-
dc.contributor.alternativeNameGuo-
dc.contributor.alternativeNameCai-
dc.contributor.alternativeName이정준-
dc.contributor.alternativeName강삼식-
dc.contributor.alternativeName신은명-
dc.contributor.alternativeNameZhou-
dc.contributor.alternativeName정지원-
dc.contributor.alternativeName김영식-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 31, no. 4, pp. 490-496-
dc.identifier.doi10.1007/s12272-001-1183-8-
dc.subject.keywordBisdemethoxycurcumin-
dc.subject.keywordDemethoxycurcumin-
dc.subject.keywordLPS-
dc.subject.keywordMacrophage-
dc.subject.keywordNF-κB-
dc.subject.keywordPaw edema-
dc.subject.localBisdemethoxycurcumin-
dc.subject.localDemethoxycurcumin-
dc.subject.localLPS-
dc.subject.localmacrophages-
dc.subject.localmacrophage-
dc.subject.localMacrophages-
dc.subject.localMacrophage-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.subject.localPaw edema-
dc.description.journalClassY-
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