DC Field | Value | Language |
---|---|---|
dc.contributor.author | L Y Guo | - |
dc.contributor.author | X F Cai | - |
dc.contributor.author | Jung Joon Lee | - |
dc.contributor.author | S S Kang | - |
dc.contributor.author | E M Shin | - |
dc.contributor.author | H Y Zhou | - |
dc.contributor.author | J W Jung | - |
dc.contributor.author | Y S Kim | - |
dc.date.accessioned | 2017-04-19T09:12:04Z | - |
dc.date.available | 2017-04-19T09:12:04Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | 10.1007/s12272-001-1183-8 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8670 | - |
dc.description.abstract | Demethoxycurcumin and bisdemethoxycurcumin are the main active ingredients isolated from Curcumae Longae Radix. Recent studies demonstrated that both compounds exhibit antioxidative and anti-inflammatory effects as well as effects on cancer cell lines. In this study, we compared the activities of demethoxycurcumin and bisdemethoxycurcumin, and both compounds were evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cycloxygenase-2 (COX-2) and nuclear factor-kappaB (NF-κB) activity in a RAW 264.7 macrophage cell line. The evaluation:results suggested that the anti-inflammatory properties of demethoxycurcumin and bisdemethoxycurcumin were attributed to the inhibition of iNOS and COX-2 expression, as initiated by the inhibition of NF-κB activity. Additionally, both of them significantly inhibited carrageenan-induced paw edema in mice. Taken together, all of the results showed that the suppressive effect of demethoxycurcumin was stronger than that of bisdemethoxycurcumin, indicating that the methoxy group had enhanced demethoxycurcumin's anti-inflammation effects. | - |
dc.publisher | Pharmaceutical Soc Korea | - |
dc.title | Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo | - |
dc.title.alternative | Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo | - |
dc.type | Article | - |
dc.citation.title | Archives of Pharmacal Research | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 496 | - |
dc.citation.startPage | 490 | - |
dc.citation.volume | 31 | - |
dc.contributor.affiliatedAuthor | Jung Joon Lee | - |
dc.contributor.alternativeName | Guo | - |
dc.contributor.alternativeName | Cai | - |
dc.contributor.alternativeName | 이정준 | - |
dc.contributor.alternativeName | 강삼식 | - |
dc.contributor.alternativeName | 신은명 | - |
dc.contributor.alternativeName | Zhou | - |
dc.contributor.alternativeName | 정지원 | - |
dc.contributor.alternativeName | 김영식 | - |
dc.identifier.bibliographicCitation | Archives of Pharmacal Research, vol. 31, no. 4, pp. 490-496 | - |
dc.identifier.doi | 10.1007/s12272-001-1183-8 | - |
dc.subject.keyword | Bisdemethoxycurcumin | - |
dc.subject.keyword | Demethoxycurcumin | - |
dc.subject.keyword | LPS | - |
dc.subject.keyword | Macrophage | - |
dc.subject.keyword | NF-κB | - |
dc.subject.keyword | Paw edema | - |
dc.subject.local | Bisdemethoxycurcumin | - |
dc.subject.local | Demethoxycurcumin | - |
dc.subject.local | LPS | - |
dc.subject.local | macrophages | - |
dc.subject.local | macrophage | - |
dc.subject.local | Macrophages | - |
dc.subject.local | Macrophage | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.subject.local | Paw edema | - |
dc.description.journalClass | Y | - |
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