DC Field | Value | Language |
---|---|---|
dc.contributor.author | N T Dat | - |
dc.contributor.author | J H Lee | - |
dc.contributor.author | Kyeong Lee | - |
dc.contributor.author | Young-Soo Hong | - |
dc.contributor.author | Y H Kim | - |
dc.contributor.author | Jung Joon Lee | - |
dc.date.accessioned | 2017-04-19T09:12:04Z | - |
dc.date.available | 2017-04-19T09:12:04Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | 10.1021/np800383q | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8671 | - |
dc.description.abstract | NF-κB is known to play a crucial role in the regulation of genes controlling the immune system, apoptosis, tumor cell growth, and tissue differentiation. Bioassay-guided fractionation of the n-hexane-soluble fraction of a methanol extract of Amorpha fruticosa afforded four new compounds, 5, 7, 8, and 9, and eight known compounds. Their structures were elucidated by spectroscopic methods. All compounds inhibited NF-κB activity, and tephrosin (1), 11-hydroxytephrosin (2), and deguelin (3) were the most active, with IC50 values of 0.11, 0.19, and 0.22 μM, respectively, in TNF-α-stimulated HeLa cell-based reporter gene assays. Further investigations showed that compounds 1, 5, and 6 blocked NF-κB/DNA binding activity and suppressed the expression of NF-κB target genes. | - |
dc.publisher | Amer Chem Soc | - |
dc.title | Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression | - |
dc.title.alternative | Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression | - |
dc.type | Article | - |
dc.citation.title | Journal of Natural Products | - |
dc.citation.number | 10 | - |
dc.citation.endPage | 1700 | - |
dc.citation.startPage | 1696 | - |
dc.citation.volume | 71 | - |
dc.contributor.affiliatedAuthor | Kyeong Lee | - |
dc.contributor.affiliatedAuthor | Young-Soo Hong | - |
dc.contributor.affiliatedAuthor | Jung Joon Lee | - |
dc.contributor.alternativeName | Dat | - |
dc.contributor.alternativeName | 이정형 | - |
dc.contributor.alternativeName | 이경 | - |
dc.contributor.alternativeName | 홍영수 | - |
dc.contributor.alternativeName | 김영호 | - |
dc.contributor.alternativeName | 이정준 | - |
dc.identifier.bibliographicCitation | Journal of Natural Products, vol. 71, no. 10, pp. 1696-1700 | - |
dc.identifier.doi | 10.1021/np800383q | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.