Viridicatumtoxin B, a new anti-MRSA agent from Penicillium so. FR11

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Title
Viridicatumtoxin B, a new anti-MRSA agent from Penicillium so. FR11
Author(s)
C J Zheng; Hyung Eun Yu; E H Kim; Won Gon Kim
Bibliographic Citation
Journal of Antibiotics, vol. 61, no. 10, pp. 633-637
Publication Year
2008
Abstract
A new tetracycline-type antibiotic named viridicatumtoxin B along with the known compound viridicatumtoxin has been isolated from the mycelium of liquid fermentation cultures of Penicillium sp. FR11. The structure of viridicatumtoxin B was determined on the basis of MS and NMR data. Viridicatumtoxin B inhibited the growth of Staphylococcus aureus including methicillin-resistant S. aureus and quinolone-resistant S. aureus with MIC (μg/ml) of 0.5, which is similar with that of vancomycin, but 8-64 times higher activity than that of tetracycline.
Keyword
antibacterialMRSApenicilliumtetracyclineviridicatumtoxin B
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/ja.2008.84
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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