DC Field | Value | Language |
---|---|---|
dc.contributor.author | Y E Kim | - |
dc.contributor.author | H B Kang | - |
dc.contributor.author | J A Park | - |
dc.contributor.author | Ki Hoan Nam | - |
dc.contributor.author | H J Kwon | - |
dc.contributor.author | Y Lee | - |
dc.date.accessioned | 2017-04-19T09:12:05Z | - |
dc.date.available | 2017-04-19T09:12:05Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1225-8687 | - |
dc.identifier.uri | 10.5483/BMBRep.2008.41.10.705 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/8680 | - |
dc.description.abstract | NF-κB is a transcriptional regulator involved in many biological processes including proliferation, survival, and differentiation. Recently, we reported that expression and activity of NF-κB is comparatively low in undifferentiated human embryonic stem (ES) cells, but increases during differentiation. Here, we found a lower expression of NF-κB p65 protein in mouse ES cells when compared with mouse embryonic fibroblast cells. Protein levels of NF-κB p65 and relB were clearly enhanced during retinoic acid-induced differentiation. Furthermore, increased DNA binding activity of NF-κB in response to TNF-α, an agonist of NF-κB signaling, was seen in differentiated but not undifferentiated mouse ES cells. Taken together with our previous data in human ES cells, it is likely that NF-κB expression and activity of the NF-κB signaling pathway is comparatively low in undifferentiated ES cells, but increases during differentiation of ES cells in general. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Upregulation of NF-κB upon differentiation of mouse embryonic stem cells | - |
dc.title.alternative | Upregulation of NF-κB upon differentiation of mouse embryonic stem cells | - |
dc.type | Article | - |
dc.citation.title | BMB Reports | - |
dc.citation.number | 10 | - |
dc.citation.endPage | 709 | - |
dc.citation.startPage | 705 | - |
dc.citation.volume | 41 | - |
dc.contributor.affiliatedAuthor | Ki Hoan Nam | - |
dc.contributor.alternativeName | 김영은 | - |
dc.contributor.alternativeName | 강호범 | - |
dc.contributor.alternativeName | 박정아 | - |
dc.contributor.alternativeName | 남기환 | - |
dc.contributor.alternativeName | 권형주 | - |
dc.contributor.alternativeName | 이영희 | - |
dc.identifier.bibliographicCitation | BMB Reports, vol. 41, no. 10, pp. 705-709 | - |
dc.identifier.doi | 10.5483/BMBRep.2008.41.10.705 | - |
dc.subject.keyword | differentiation | - |
dc.subject.keyword | embryonic stem cells | - |
dc.subject.keyword | expression | - |
dc.subject.keyword | NF-κB | - |
dc.subject.keyword | upregulation | - |
dc.subject.local | differentiation | - |
dc.subject.local | Differentiation | - |
dc.subject.local | embryonic stem cell | - |
dc.subject.local | embryonic stem cells | - |
dc.subject.local | Embryonic stem cell | - |
dc.subject.local | Embryonic stem cells | - |
dc.subject.local | embryonic stem cell (ESC) | - |
dc.subject.local | expression | - |
dc.subject.local | Expression | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.subject.local | up-regulation | - |
dc.subject.local | upregulation | - |
dc.subject.local | Upregulation& | - |
dc.description.journalClass | Y | - |
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